open access

Vol 44, No 3 (2012 Jul-Sep)
Review articles
Published online: 2012-10-22
Submitted: 2012-10-22
Accepted: 2012-10-22
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Pharmacokinetic-pharmacodynamic modelling of antibiotic therapy in severe sepsis

Wiesława Duszyńska
Anaesthesiol Intensive Ther 2012;44(3):158-164.

open access

Vol 44, No 3 (2012 Jul-Sep)
Review articles
Published online: 2012-10-22
Submitted: 2012-10-22
Accepted: 2012-10-22

Abstract

The antibiotic treatment of severe sepsis poses an increasing challenge in ICU. The multidrug resistance and diverse pharmacokinetics of antibiotics requires a different approach on antibiotic therapy because of the inadequate serum antibiotic levels found in ICU patients. The current guidelines or recommendations of antibiotic treatment take into account the pharmacokinetic parameters in determining the proper dosage. The recommended antibiotic treatment of severe sepsis requires daily assessment and dosage adjustment based on measurements of antibiotic concentrations in order to optimize the treatment.

Abstract

The antibiotic treatment of severe sepsis poses an increasing challenge in ICU. The multidrug resistance and diverse pharmacokinetics of antibiotics requires a different approach on antibiotic therapy because of the inadequate serum antibiotic levels found in ICU patients. The current guidelines or recommendations of antibiotic treatment take into account the pharmacokinetic parameters in determining the proper dosage. The recommended antibiotic treatment of severe sepsis requires daily assessment and dosage adjustment based on measurements of antibiotic concentrations in order to optimize the treatment.

Get Citation

Keywords

severe sepsis, antibiotic treatment, PK/PD modelling

About this article
Title

Pharmacokinetic-pharmacodynamic modelling of antibiotic therapy in severe sepsis

Journal

Anaesthesiology Intensive Therapy

Issue

Vol 44, No 3 (2012 Jul-Sep)

Pages

158-164

Published online

2012-10-22

Bibliographic record

Anaesthesiol Intensive Ther 2012;44(3):158-164.

Keywords

severe sepsis
antibiotic treatment
PK/PD modelling

Authors

Wiesława Duszyńska

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