open access

Vol 88, No 5 (2020)
Letter to the Editor
Published online: 2020-10-24
Submitted: 2020-06-05
Accepted: 2020-06-08
Get Citation

Vascular microthrombosis associated with increased interleukin-6. A severe acute respiratory distress syndrome in COVID-19 patients treated with tocilizumab

Niayesh Mohebbi, Atefeh Abedini, Reza Lashgari, Fatemeh Razavi, Mohammad Varahram, Arda Kiani
DOI: 10.5603/ARM.a2020.0123
·
Pubmed: 33169824
·
Adv Respir Med 2020;88(5):468-469.

open access

Vol 88, No 5 (2020)
LETTERS
Published online: 2020-10-24
Submitted: 2020-06-05
Accepted: 2020-06-08

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

COVID-19; interleukin-6; tocilizumab

About this article
Title

Vascular microthrombosis associated with increased interleukin-6. A severe acute respiratory distress syndrome in COVID-19 patients treated with tocilizumab

Journal

Advances in Respiratory Medicine

Issue

Vol 88, No 5 (2020)

Article type

Letter to the Editor

Pages

468-469

Published online

2020-10-24

DOI

10.5603/ARM.a2020.0123

Pubmed

33169824

Bibliographic record

Adv Respir Med 2020;88(5):468-469.

Keywords

COVID-19
interleukin-6
tocilizumab

Authors

Niayesh Mohebbi
Atefeh Abedini
Reza Lashgari
Fatemeh Razavi
Mohammad Varahram
Arda Kiani

References (10)
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  2. Leisman DE, Deutschman CS, Legrand M. Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Med. 2020; 46(6): 1105–1108.
  3. Sungurlu S, Kuppy J, Balk RA. Role of antithrombin III and tissue factor pathway in the pathogenesis of sepsis. Crit Care Clin. 2020; 36(2): 255–265.
  4. Lee DD, Schwarz MA. Cell-Cell communication breakdown and endothelial dysfunction. Crit Care Clin. 2020; 36(2): 189–200.
  5. Libby P, Simon DI. Inflammation and thrombosis: the clot thickens. Circulation. 2001; 103(13): 1718–1720.
  6. Toussaint S, Gerlach H. Activated protein C for sepsis. N Engl J Med. 2009; 361(27): 2646–2652.
  7. McGonagle D, Sharif K, O'Regan A, et al. The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun Rev. 2020; 19(6): 102537.
  8. Bernardo A, Ball C, Nolasco L, et al. Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow. Blood. 2004; 104(1): 100–106.
  9. Nishimoto N, Terao K, Mima T, et al. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood. 2008; 112(10): 3959–3964.
  10. Cabanillas G, Popescu-Martinez A. N-Acetylcysteine for relapsing thrombotic thrombocytopenic purpura: more evidence of a promising drug. Am J Ther. 2016; 23(5): e1277–e1279.

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