open access

Vol 86, No 4 (2018)
ORIGINAL PAPERS
Published online: 2018-08-15
Submitted: 2018-04-22
Accepted: 2018-08-13
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The prevalence and predicting factors of pulmonary thromboembolism in patients with exacerbated chronic obstructive pulmonary disease

Mohammad Davoodi, Boshra Rezvankhah, Keivan Gohari Moghadam, Amir Pejman Hashemi Taheri
DOI: 10.5603/ARM.a2018.0025
·
Pubmed: 30110117
·
Adv Respir Med 2018;86(4):168-171.

open access

Vol 86, No 4 (2018)
ORIGINAL PAPERS
Published online: 2018-08-15
Submitted: 2018-04-22
Accepted: 2018-08-13

Abstract

Introduction: The risk of pulmonary thromboembolism (PTE) in patients with exacerbated chronic obstructive pulmonary disease
(e-COPD) is higher than in non-COPD states. The study aimed to evaluate the prevalence and the parameters that are critical for
finding the incidence of PTE in patients with e-COPD.

Material and methods: This cross-sectional study was performed on 68 consecutive patients with the e-COPD, referred to the
Pulmonary Disease Department at the Shariati Hospital in Tehran between 2013 and 2014. In addition to collecting data on the
history of disease and physical examination, arterial blood sampling, spirometry, electrocardiography and echocardiography were
performed for all patients. All subjects underwent computed tomography pulmonary angiography (CT-PA) as a method of choice
for diagnosing PTE.

Results: Out of 68 cases, five (7.4%) had CT angiography findings suggesting PTE. These patients were all male and had a higher
mean age (79 vs. 65 years), lower mean systolic blood pressure (88.36 vs. 118.33 mmHg), and a higher mean heart rate (133.12
vs 90.33 beats/min), compared to e-COPD patients without PTE. Arterial blood gas analysis in individuals with PTE demonstrated
a lower HCO3 (2.33 vs. 9.44 mEq/l) and PCO2 (44.35 vs. 51.43 mm Hg) levels. The mean left ventricular ejection fraction (LVEF)
was lower in patients with PTE (34.14 ± 4.49% vs. 46.94 ± 8.27%).

Conclusion: The prevalence of PTE in our series of patients with e-COPD was 7.4%. According to the study results, male gender,
advanced age, hypotension, tachycardia, and respiratory alkalosis are factors indicating possible PTE among subjects with e-
COPD.

Abstract

Introduction: The risk of pulmonary thromboembolism (PTE) in patients with exacerbated chronic obstructive pulmonary disease
(e-COPD) is higher than in non-COPD states. The study aimed to evaluate the prevalence and the parameters that are critical for
finding the incidence of PTE in patients with e-COPD.

Material and methods: This cross-sectional study was performed on 68 consecutive patients with the e-COPD, referred to the
Pulmonary Disease Department at the Shariati Hospital in Tehran between 2013 and 2014. In addition to collecting data on the
history of disease and physical examination, arterial blood sampling, spirometry, electrocardiography and echocardiography were
performed for all patients. All subjects underwent computed tomography pulmonary angiography (CT-PA) as a method of choice
for diagnosing PTE.

Results: Out of 68 cases, five (7.4%) had CT angiography findings suggesting PTE. These patients were all male and had a higher
mean age (79 vs. 65 years), lower mean systolic blood pressure (88.36 vs. 118.33 mmHg), and a higher mean heart rate (133.12
vs 90.33 beats/min), compared to e-COPD patients without PTE. Arterial blood gas analysis in individuals with PTE demonstrated
a lower HCO3 (2.33 vs. 9.44 mEq/l) and PCO2 (44.35 vs. 51.43 mm Hg) levels. The mean left ventricular ejection fraction (LVEF)
was lower in patients with PTE (34.14 ± 4.49% vs. 46.94 ± 8.27%).

Conclusion: The prevalence of PTE in our series of patients with e-COPD was 7.4%. According to the study results, male gender,
advanced age, hypotension, tachycardia, and respiratory alkalosis are factors indicating possible PTE among subjects with e-
COPD.

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Keywords

pulmonary thromboembolism (PTE), exacerbated COPD (e-COPD), computed tomography pulmonary angiography (CT-PA), systolic blood pressure (SBP), left ventricular ejection fraction (LVEF)

About this article
Title

The prevalence and predicting factors of pulmonary thromboembolism in patients with exacerbated chronic obstructive pulmonary disease

Journal

Advances in Respiratory Medicine

Issue

Vol 86, No 4 (2018)

Pages

168-171

Published online

2018-08-15

DOI

10.5603/ARM.a2018.0025

Pubmed

30110117

Bibliographic record

Adv Respir Med 2018;86(4):168-171.

Keywords

pulmonary thromboembolism (PTE)
exacerbated COPD (e-COPD)
computed tomography pulmonary angiography (CT-PA)
systolic blood pressure (SBP)
left ventricular ejection fraction (LVEF)

Authors

Mohammad Davoodi
Boshra Rezvankhah
Keivan Gohari Moghadam
Amir Pejman Hashemi Taheri

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