open access

Vol 85, No 6 (2017)
CASE REPORTS
Published online: 2017-12-13
Submitted: 2017-09-04
Accepted: 2017-10-04
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Spontaneous resolution of nitrofurantoin-induced chronic pulmonary toxicity presenting with respiratory failure

Elias Mir, Javed A Malik, Shabir A Lone, Ramees Mohi-ud-din, Majid Khalil
DOI: 10.5603/ARM.2017.0057
·
Adv Respir Med 2017;85(6):333-338.

open access

Vol 85, No 6 (2017)
CASE REPORTS
Published online: 2017-12-13
Submitted: 2017-09-04
Accepted: 2017-10-04

Abstract

Nitrofurantoin is one of the most common drugs implicated in drug-induced pulmonary toxicities, the manifestations of which range from dose-independent acute self-limiting reactions to chronic dose-dependent pathologies. The severity of these pulmonary adverse effects may range from trivial hypersensitivity reactions to extensive and irreversible lung fibrosis leading to respiratory failure and death. Symptomatic and supportive treatment in addition to discontinuation of the drug usually suffices for the management of mild reactions. Corticosteroids have been traditionally used to relieve the symptoms and hasten the resolution of pulmonary lesions in case of severe toxicities. However conclusive evidence in the form of controlled studies in favor of this routine use is lacking. We report a case of an elderly lady who presented to us in respiratory failure due to nitrofurantoin induced chronic lung disease. The patient’s symptoms and blood gas abnormalities resolved spontaneously over the course of 6 months after stopping the drug. Radiological lesions including those suggestive of apparently permanent fibrosis also resolved during this time. Corticosteroids, inhalational or systemic, were not used. Spontaneous normalization of clinico-radiological features in nitrofurantoin induced chronic lung disease presenting with respiratory failure has rarely been reported previously. The related literature is also reviewed.

Abstract

Nitrofurantoin is one of the most common drugs implicated in drug-induced pulmonary toxicities, the manifestations of which range from dose-independent acute self-limiting reactions to chronic dose-dependent pathologies. The severity of these pulmonary adverse effects may range from trivial hypersensitivity reactions to extensive and irreversible lung fibrosis leading to respiratory failure and death. Symptomatic and supportive treatment in addition to discontinuation of the drug usually suffices for the management of mild reactions. Corticosteroids have been traditionally used to relieve the symptoms and hasten the resolution of pulmonary lesions in case of severe toxicities. However conclusive evidence in the form of controlled studies in favor of this routine use is lacking. We report a case of an elderly lady who presented to us in respiratory failure due to nitrofurantoin induced chronic lung disease. The patient’s symptoms and blood gas abnormalities resolved spontaneously over the course of 6 months after stopping the drug. Radiological lesions including those suggestive of apparently permanent fibrosis also resolved during this time. Corticosteroids, inhalational or systemic, were not used. Spontaneous normalization of clinico-radiological features in nitrofurantoin induced chronic lung disease presenting with respiratory failure has rarely been reported previously. The related literature is also reviewed.
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Keywords

nitrofurantoin, pulmonary, lung, drug-induced ILD, respiratory failure, corticosteroids

About this article
Title

Spontaneous resolution of nitrofurantoin-induced chronic pulmonary toxicity presenting with respiratory failure

Journal

Advances in Respiratory Medicine

Issue

Vol 85, No 6 (2017)

Pages

333-338

Published online

2017-12-13

DOI

10.5603/ARM.2017.0057

Bibliographic record

Adv Respir Med 2017;85(6):333-338.

Keywords

nitrofurantoin
pulmonary
lung
drug-induced ILD
respiratory failure
corticosteroids

Authors

Elias Mir
Javed A Malik
Shabir A Lone
Ramees Mohi-ud-din
Majid Khalil

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