open access

Vol 81, No 5 (2013)
CASE REPORTS
Submitted: 2013-08-22
Accepted: 2013-08-22
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Interstitial pneumonia connected with rituximab therapy — case report

Dorota Wyrostkiewicz, Wojciech Skorupa, Inga Barańska, Jan Kuś
Pneumonol Alergol Pol 2013;81(5):453-459.

open access

Vol 81, No 5 (2013)
CASE REPORTS
Submitted: 2013-08-22
Accepted: 2013-08-22

Abstract

Rituximab (RTX) is a monoclonal antibody against the CD20 antigen found on the surface of B cells. RTX causes cell lysis and is therefore used to treat lymphomas, leukaemias, transplant rejection and certain autoimmune disorders. Pulmonary adverse events associated with RTX have been reported in literature. We describe a patient with follicular lymphoma treated with R-CHOP scheme (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) who had pulmonary symptoms during chemotherapy which were diagnosed as rituximab-induced interstitial pneumonia. Symptoms and radiological changes resolved with prednisone therapy.

Abstract

Rituximab (RTX) is a monoclonal antibody against the CD20 antigen found on the surface of B cells. RTX causes cell lysis and is therefore used to treat lymphomas, leukaemias, transplant rejection and certain autoimmune disorders. Pulmonary adverse events associated with RTX have been reported in literature. We describe a patient with follicular lymphoma treated with R-CHOP scheme (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) who had pulmonary symptoms during chemotherapy which were diagnosed as rituximab-induced interstitial pneumonia. Symptoms and radiological changes resolved with prednisone therapy.

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Keywords

interstitial pneumonia, adverse effects, monoclonal antibodies, rituximab

About this article
Title

Interstitial pneumonia connected with rituximab therapy — case report

Journal

Advances in Respiratory Medicine

Issue

Vol 81, No 5 (2013)

Pages

453-459

Bibliographic record

Pneumonol Alergol Pol 2013;81(5):453-459.

Keywords

interstitial pneumonia
adverse effects
monoclonal antibodies
rituximab

Authors

Dorota Wyrostkiewicz
Wojciech Skorupa
Inga Barańska
Jan Kuś

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