open access

Vol 72, No 1-2 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Autoimmune thyroid diseases in patients with primary pulmonary hypertension

Liliana Wawrzyńska, Marcin Kurzyna, Paweł Kuca, Anna Fijałkowska, Jarosław Kober, Michał Florczyk, Adam Torbicki
Pneumonol Alergol Pol 2004;72(1-2):19-22.

open access

Vol 72, No 1-2 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Abnormal metabolism due to thyroid disorders could cause the additional significant right ventricular(RV) overload in patients with primary pulmonary hypertension (PPH). The purpose of this study was the prospective determination of autoimmune thyroid status in PPH patients.
Material: 45 patients (33 women and 12 men, mean age 38 years ± 13) with moderate and severe PPH (mean pulmonary artery pressure 61 mm Hg ± 18 mm Hg). PPH was diagnosed when other reason of pulmonary hypertension had been excluded especially thromboembolic, venous and hypoxemic.
Methods: Titer of antibodies to thyroglobulin and thyroid peroxidase were measured. Thyroid gland dysfunction was determined by biochemical measurements of thyrotropin and free thyroxine; thyroid ultrasonographic examination was also performed. The prevalence of thyroid autoantibodies is estimated at 13% in general population.
Results: In 14 patients (31%) increased titer of thyroid antibodies was found in our group. Hyperthyroidism was recognized in 2 patients and in 3 cases we diagnosed hypothyroidism with high antibodies level requiring treatment. Ultrasonographic abnormalities were revealed in 21 patients (nodular changes - 11 patients, fibrosis -3 patients, chronic inflammation symptoms - 7). Ultrasonographic abnormalities were present in all patients with detectable antithyroid antibodies. We haven't confirmed more frequent prevalence of hormonal disorders in patient treated with prostacycline's analogues.
Conclusion: The prevalence of autoimmune thyroid diseases is about 3 times higher in PPH patients than in general population. The treatment of patients with clinically evident hyper- or hypothyroidism is necessary. The monitoring of clinically silent disorders seems to be recommended especially prior to lung transplantation qualification.

Abstract

Abnormal metabolism due to thyroid disorders could cause the additional significant right ventricular(RV) overload in patients with primary pulmonary hypertension (PPH). The purpose of this study was the prospective determination of autoimmune thyroid status in PPH patients.
Material: 45 patients (33 women and 12 men, mean age 38 years ± 13) with moderate and severe PPH (mean pulmonary artery pressure 61 mm Hg ± 18 mm Hg). PPH was diagnosed when other reason of pulmonary hypertension had been excluded especially thromboembolic, venous and hypoxemic.
Methods: Titer of antibodies to thyroglobulin and thyroid peroxidase were measured. Thyroid gland dysfunction was determined by biochemical measurements of thyrotropin and free thyroxine; thyroid ultrasonographic examination was also performed. The prevalence of thyroid autoantibodies is estimated at 13% in general population.
Results: In 14 patients (31%) increased titer of thyroid antibodies was found in our group. Hyperthyroidism was recognized in 2 patients and in 3 cases we diagnosed hypothyroidism with high antibodies level requiring treatment. Ultrasonographic abnormalities were revealed in 21 patients (nodular changes - 11 patients, fibrosis -3 patients, chronic inflammation symptoms - 7). Ultrasonographic abnormalities were present in all patients with detectable antithyroid antibodies. We haven't confirmed more frequent prevalence of hormonal disorders in patient treated with prostacycline's analogues.
Conclusion: The prevalence of autoimmune thyroid diseases is about 3 times higher in PPH patients than in general population. The treatment of patients with clinically evident hyper- or hypothyroidism is necessary. The monitoring of clinically silent disorders seems to be recommended especially prior to lung transplantation qualification.
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Keywords

autoimmune thyroid disease (AITD); primary pulmonary hypertension (PPH)

About this article
Title

Autoimmune thyroid diseases in patients with primary pulmonary hypertension

Journal

Advances in Respiratory Medicine

Issue

Vol 72, No 1-2 (2004)

Pages

19-22

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2004;72(1-2):19-22.

Keywords

autoimmune thyroid disease (AITD)
primary pulmonary hypertension (PPH)

Authors

Liliana Wawrzyńska
Marcin Kurzyna
Paweł Kuca
Anna Fijałkowska
Jarosław Kober
Michał Florczyk
Adam Torbicki

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