open access

Vol 72, No 11-12 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Organizing pneumonia – own experiences with clarthromycin treatment

Elżbieta Radzikowska, Elżbieta Wiatr, Renata Langfort, Iwona Bestry, Piotr Rudziński, Kazimierz Roszkowski
Pneumonol Alergol Pol 2004;72(11-12):493-498.

open access

Vol 72, No 11-12 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Organising pneumonia (OP) is a rare syndrome that has been associated with a variety of underlying disorders, including infections, collagen vascular diseases, toxic fumes, cancer, drugs and radiotherapy. Cryptogenic form is also observed. Steroids are usually effective in the treatment of OP, but other treatment regimens have been used as well. We present 5 women with OP, age ranged 57-76 years (mean – 67 years). Two of them were smokers and three were non-smokers. One patient was treated because of hyperthyreosis, one of COPD, and four had a hypertension. Four of them were diagnosed by the open lung biopsy and one by transbronchial lung biopsy. Dyspnoea (100%), cough (100%), fever (80%), loste of weight (40%), chest pain (20%), were the most frequently noticed symptoms. All patients had bilateral consolidations with areas of ground glass attenuations at chest x-ray and HRCT. Migratory pattern of them was observed in four patients. Significant elevation of antibodies titers against Chlamydia pneumoniae was revealed in two patients. In all patients clarithromycin in a dose 0,5g b.d. was administrated. Complete clinical and radiological remission was obtained after 3 months of clarithromycin therapy in 3 patients (one had Chlamydia antibodies). Two patients had not obtained significant improvement during the first two weeks of therapy so prednisolon in a dose 0,5mg/kg/d was introduced. Also complete remission was noticed in these patients. The observation period ranged from 8 months to 4 years (mean – 34 months). Our study confirms that OP can be treated by the use of clarithromycin. It may be the alternative treatment, particularly for patients in whom probability of adverse reactions in the course of steroid treatment is high.
Pneumonol. Alergol. Pol. 2004, 72, 493:498

Keywords

organizing pneumonia; clarithromcin

About this article
Title

Organizing pneumonia – own experiences with clarthromycin treatment

Journal

Advances in Respiratory Medicine

Issue

Vol 72, No 11-12 (2004)

Pages

493-498

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2004;72(11-12):493-498.

Keywords

organizing pneumonia
clarithromcin

Authors

Elżbieta Radzikowska
Elżbieta Wiatr
Renata Langfort
Iwona Bestry
Piotr Rudziński
Kazimierz Roszkowski

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