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The assessment of reversibility in airway obstruction
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Abstract
In the medical literature there have been described some methods to determine bronchodilator response. They are different because of the required percentage increase in FEV1 and /or FVC and the way of expressing results -as the percent of predicted or initial value. This study on 38 subjects evaluated that there is better bronchodilator responses when the results are presented as the percentage of the initial value compared with the predicted value. The intensivity of impovement in FEV1 depends on the baseline airway obstruction. There are more meaningfull responses in subjects with ’poor’ initial value when using the criteria of change in FEV1 as a percentage of initial value. About 10% of positive responses are misunderstood as ‘poor’ when it was considered improvement only in FEV1 (they are positive with reference only to FVC).
Pneumonol. Alergol. Pol. 2004, 72, 499:504
Abstract
In the medical literature there have been described some methods to determine bronchodilator response. They are different because of the required percentage increase in FEV1 and /or FVC and the way of expressing results -as the percent of predicted or initial value. This study on 38 subjects evaluated that there is better bronchodilator responses when the results are presented as the percentage of the initial value compared with the predicted value. The intensivity of impovement in FEV1 depends on the baseline airway obstruction. There are more meaningfull responses in subjects with ’poor’ initial value when using the criteria of change in FEV1 as a percentage of initial value. About 10% of positive responses are misunderstood as ‘poor’ when it was considered improvement only in FEV1 (they are positive with reference only to FVC).
Pneumonol. Alergol. Pol. 2004, 72, 499:504
Keywords
reversibility; predicted and initial value
About this articleTitle
The assessment of reversibility in airway obstruction
Journal
Advances in Respiratory Medicine
Issue
Pages
499-504
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2004;72(11-12):499-504.
Keywords
reversibility
predicted and initial value
Authors
Izabela Toczyska
Wojciech Lubiński
Andrzej Chciałowski