open access

Vol 72, No 11-12 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Assesment of antioxidative enzymes activity and intensification of lipids peroxidation in asthmatic patients.

Barbara Rogala, Renata Poloniak, Alicja Grzanka, Nelly Ciesielska-Kopacz, Ewa Birkner
Pneumonol Alergol Pol 2004;72(11-12):472-476.

open access

Vol 72, No 11-12 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract


Chronic immunoalergic in flammatory reaction plays a key role in pathogenesis of asthma. Importance of free oxygen radicals in mechanism of chronic inflammatory process has been proved. Activity of two antioxidative enzymes: isoenzymes of superoxide dismutase (SOD), glutathione peroxidase (POX), and concentration of malondialdehyde (MDA) in serum and erythrocytes in asthmatics during exacerbation and improvement of disease were assessed. Disturbances in oxidative system in asthmatic patients have been observed. Lack of significant differences in antioxidative indexes between a period of exacerbation, not complicated by infection and a period of improvement indicates a pathophysiological role of chronic oxygenic stress in asthma. It has been also shown that bacterial infection disturbes efficiency of antioxidative mechanisms.
Pneumonol. Alergol. Pol. 2004, 72, 472-476

Abstract


Chronic immunoalergic in flammatory reaction plays a key role in pathogenesis of asthma. Importance of free oxygen radicals in mechanism of chronic inflammatory process has been proved. Activity of two antioxidative enzymes: isoenzymes of superoxide dismutase (SOD), glutathione peroxidase (POX), and concentration of malondialdehyde (MDA) in serum and erythrocytes in asthmatics during exacerbation and improvement of disease were assessed. Disturbances in oxidative system in asthmatic patients have been observed. Lack of significant differences in antioxidative indexes between a period of exacerbation, not complicated by infection and a period of improvement indicates a pathophysiological role of chronic oxygenic stress in asthma. It has been also shown that bacterial infection disturbes efficiency of antioxidative mechanisms.
Pneumonol. Alergol. Pol. 2004, 72, 472-476
Get Citation

Keywords

bronchial asthma; free oxygen radicals; enzymatic antioxidants; malondialdehyde

About this article
Title

Assesment of antioxidative enzymes activity and intensification of lipids peroxidation in asthmatic patients.

Journal

Advances in Respiratory Medicine

Issue

Vol 72, No 11-12 (2004)

Pages

472-476

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2004;72(11-12):472-476.

Keywords

bronchial asthma
free oxygen radicals
enzymatic antioxidants
malondialdehyde

Authors

Barbara Rogala
Renata Poloniak
Alicja Grzanka
Nelly Ciesielska-Kopacz
Ewa Birkner

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