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Assesment of antioxidative enzymes activity and intensification of lipids peroxidation in asthmatic patients.
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Abstract
Chronic immunoalergic in flammatory reaction plays a key role in pathogenesis of asthma. Importance of free oxygen radicals in mechanism of chronic inflammatory process has been proved. Activity of two antioxidative enzymes: isoenzymes of superoxide dismutase (SOD), glutathione peroxidase (POX), and concentration of malondialdehyde (MDA) in serum and erythrocytes in asthmatics during exacerbation and improvement of disease were assessed. Disturbances in oxidative system in asthmatic patients have been observed. Lack of significant differences in antioxidative indexes between a period of exacerbation, not complicated by infection and a period of improvement indicates a pathophysiological role of chronic oxygenic stress in asthma. It has been also shown that bacterial infection disturbes efficiency of antioxidative mechanisms.
Pneumonol. Alergol. Pol. 2004, 72, 472-476
Abstract
Chronic immunoalergic in flammatory reaction plays a key role in pathogenesis of asthma. Importance of free oxygen radicals in mechanism of chronic inflammatory process has been proved. Activity of two antioxidative enzymes: isoenzymes of superoxide dismutase (SOD), glutathione peroxidase (POX), and concentration of malondialdehyde (MDA) in serum and erythrocytes in asthmatics during exacerbation and improvement of disease were assessed. Disturbances in oxidative system in asthmatic patients have been observed. Lack of significant differences in antioxidative indexes between a period of exacerbation, not complicated by infection and a period of improvement indicates a pathophysiological role of chronic oxygenic stress in asthma. It has been also shown that bacterial infection disturbes efficiency of antioxidative mechanisms.
Pneumonol. Alergol. Pol. 2004, 72, 472-476
Keywords
bronchial asthma; free oxygen radicals; enzymatic antioxidants; malondialdehyde
About this articleTitle
Assesment of antioxidative enzymes activity and intensification of lipids peroxidation in asthmatic patients.
Journal
Advances in Respiratory Medicine
Issue
Pages
472-476
Published online
2008-02-18
Bibliographic record
Pneumonol Alergol Pol 2004;72(11-12):472-476.
Keywords
bronchial asthma
free oxygen radicals
enzymatic antioxidants
malondialdehyde
Authors
Barbara Rogala
Renata Poloniak
Alicja Grzanka
Nelly Ciesielska-Kopacz
Ewa Birkner