open access

Vol 72, No 3-4 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Organizing pneumonia - analysis of 18 own cases

Elżbieta Radzikowska, Elżbieta Wiatr, Paweł Remiszewski, Iwona Bestry, Jacek Grudny, Renata Langfort, Janusz Szopiński, Jacek Zych, Monika Płodziszewska, Piotr Rudziński, Dariusz Gawryluk, Barbara Roszkowska, Kazimierz Roszkowski
Pneumonol Alergol Pol 2004;72(3-4):99-104.

open access

Vol 72, No 3-4 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

Organizing pneumonia (OP) is a rarely diagnosed disease, however the incidence ratio was estimated as 6-7 /100 000. Disease can occur in cryptogenic form or as a secondary reaction to various noxious agents, drugs, and ionising radiation, as a concomitant disease to infections, lympho- and myeloproliferative disorders, and connective tissue diseases. Symptoms of OP are non-specific therefore lung biopsy and histological examination are necessary for diagnosis. Eighteen cases of OP, 15 women and 3 men, aged 40 to 76 years, are presented with analysis of clinicopathological characteristic and therapeutic problems. In all cases diagnosis was confirmedby open lung biopsy. In one case radiotherapy and in one transtuzumab treatment was the cause of OP. In further 3 women atybodies against Chlamydia pneumoniae and in one -against Mycoplasma pneumoniae were found in serum. Probably Hashimoto disease was the cause of one case. In 12 patients the OP was idiopathic. Majority of patients were treated by prednisone (0.5mg/kg). In one patient regression without any treatment was noticed and in other one - after cessation of transtuzumab. Five women were treated by clarithromycine. In 3 of them regression was observed but in other 2 corticotherapy was necessary. The observation period ranged from 1 month to 9 years, mean 34 months.

Abstract

Organizing pneumonia (OP) is a rarely diagnosed disease, however the incidence ratio was estimated as 6-7 /100 000. Disease can occur in cryptogenic form or as a secondary reaction to various noxious agents, drugs, and ionising radiation, as a concomitant disease to infections, lympho- and myeloproliferative disorders, and connective tissue diseases. Symptoms of OP are non-specific therefore lung biopsy and histological examination are necessary for diagnosis. Eighteen cases of OP, 15 women and 3 men, aged 40 to 76 years, are presented with analysis of clinicopathological characteristic and therapeutic problems. In all cases diagnosis was confirmedby open lung biopsy. In one case radiotherapy and in one transtuzumab treatment was the cause of OP. In further 3 women atybodies against Chlamydia pneumoniae and in one -against Mycoplasma pneumoniae were found in serum. Probably Hashimoto disease was the cause of one case. In 12 patients the OP was idiopathic. Majority of patients were treated by prednisone (0.5mg/kg). In one patient regression without any treatment was noticed and in other one - after cessation of transtuzumab. Five women were treated by clarithromycine. In 3 of them regression was observed but in other 2 corticotherapy was necessary. The observation period ranged from 1 month to 9 years, mean 34 months.
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Keywords

organizing pneumonia; diagnosis

About this article
Title

Organizing pneumonia - analysis of 18 own cases

Journal

Advances in Respiratory Medicine

Issue

Vol 72, No 3-4 (2004)

Pages

99-104

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2004;72(3-4):99-104.

Keywords

organizing pneumonia
diagnosis

Authors

Elżbieta Radzikowska
Elżbieta Wiatr
Paweł Remiszewski
Iwona Bestry
Jacek Grudny
Renata Langfort
Janusz Szopiński
Jacek Zych
Monika Płodziszewska
Piotr Rudziński
Dariusz Gawryluk
Barbara Roszkowska
Kazimierz Roszkowski

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