open access

Vol 72, No 5-6 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22
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Granular cell tumor - a rare, benign neoplasm of respiratory tract. Analysis of cases diagnosed in Institute of Tuberculosis and Lung DISEASES

Ewa Szczepulska-Wójcik, Renata Langfort, Włodzimierz Kupis, Dorota Giedronowicz, Elżbieta Wiatr, Naim Quandil, Iwona Kamińska, Małgorzata Szołkowska
Pneumonol Alergol Pol 2004;72(5-6):187-193.

open access

Vol 72, No 5-6 (2004)
ORIGINAL PAPERS
Published online: 2008-02-18
Submitted: 2013-02-22

Abstract

The granular cell tumor (GCT) is a nodul that arises most commonly in the skin, the breast or the tongue. The vast majority are benign. Approximately 6-10% of granular cell tumors have been reported in the lower respiratory tract. The clinical, pathological and immunohistochemical findings of elevencases are described in our material consisted of 6 males and 5 females aged from 35 to 58 years (median, 46 years). The GCT were solitary lesions in all our patients. The tumors were located in trachea (6 cases) and in bronchus (5 cases). They were found during bronchoscopy performed because of symptoms of pneumonia, lung cancer and hemoptysis or dyspnea alone. Diameter of the tumors ranged from 0.2-2.5 cm (median 1.2 cm). Six tumors were surgically excised and 5 were endoscopicaly removed. Pulmonary GCT behave in a benign fashion. It was observed that tumors of less than 8 mm were more amenable to endoscopic removal and larger tumors were more likely to infiltrate through the bronchial wall. Histologicaly, the GCT showed submucosal infiltrates of round or oval cells with abundant granular cytoplasm. The tumors cells were positive for S-100 protein, neuron specific enolase, CD68 and vimentin. Our immunohistochemical results are consistent with this concept.

Abstract

The granular cell tumor (GCT) is a nodul that arises most commonly in the skin, the breast or the tongue. The vast majority are benign. Approximately 6-10% of granular cell tumors have been reported in the lower respiratory tract. The clinical, pathological and immunohistochemical findings of elevencases are described in our material consisted of 6 males and 5 females aged from 35 to 58 years (median, 46 years). The GCT were solitary lesions in all our patients. The tumors were located in trachea (6 cases) and in bronchus (5 cases). They were found during bronchoscopy performed because of symptoms of pneumonia, lung cancer and hemoptysis or dyspnea alone. Diameter of the tumors ranged from 0.2-2.5 cm (median 1.2 cm). Six tumors were surgically excised and 5 were endoscopicaly removed. Pulmonary GCT behave in a benign fashion. It was observed that tumors of less than 8 mm were more amenable to endoscopic removal and larger tumors were more likely to infiltrate through the bronchial wall. Histologicaly, the GCT showed submucosal infiltrates of round or oval cells with abundant granular cytoplasm. The tumors cells were positive for S-100 protein, neuron specific enolase, CD68 and vimentin. Our immunohistochemical results are consistent with this concept.
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Keywords

granular cell tumor; benign neoplasm; bronchus; trachea

About this article
Title

Granular cell tumor - a rare, benign neoplasm of respiratory tract. Analysis of cases diagnosed in Institute of Tuberculosis and Lung DISEASES

Journal

Advances in Respiratory Medicine

Issue

Vol 72, No 5-6 (2004)

Pages

187-193

Published online

2008-02-18

Bibliographic record

Pneumonol Alergol Pol 2004;72(5-6):187-193.

Keywords

granular cell tumor
benign neoplasm
bronchus
trachea

Authors

Ewa Szczepulska-Wójcik
Renata Langfort
Włodzimierz Kupis
Dorota Giedronowicz
Elżbieta Wiatr
Naim Quandil
Iwona Kamińska
Małgorzata Szołkowska

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