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Vol 74, No 4 (2006)
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Published online: 2006-09-08
Submitted: 2013-02-22
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The role of interleukin 17 cytokine family in inducing allergic inflammation in the pulmonary tract

Aleksandra Semik-Orzech, Adam Barczyk, Władysław Pierzchała
Pneumonol Alergol Pol 2006;74(4):409-413.

open access

Vol 74, No 4 (2006)
REVIEWS
Published online: 2006-09-08
Submitted: 2013-02-22

Abstract

IL-17 family is a group of proinflammatory cytokines produced by activated memory T-cells. These cytokines play an important role in the development of cellular and humoral mechanisms of immunological responses lying at the basis of allergic disorders. The aim of this paper is to present the current knowledge on the role of interleukin 17 cytokine family in the pathogenesis of allergic disorders of the respiratory tract. IL-17A (as well as IL-17F) plays role in the development of airway hyperresponsiveness through activation of allergen-specific T-cells. Levels of IL-17A are elevated in sputum of asthmatic patients and correlate with airway hyperresponsiveness to methacholine. However, it remains fact, that the main effect of IL-17A in the pulmonary tract is recrutation of polymorphonuclear leukocytes, depending on CXC chemokine release from stromal cells. IL-17E evokes different immunological responses. This cytokine participates in the development of Th2-cell-dependent immunological response and the coexisting pathological tissue changes. These actions take place mainly through the induction of synthesis of the Th2 cell-derived cytokines (IL-4, IL-5, IL-13) and the development of eosinophilic inflammation. It is thought, that the character of the immunological response evoked by different cytokines of IL-17 family depends on the differences between the spatial structure of their fragments including disulfi de bridges and that these differences determine their receptor interactions and biological functions.

Abstract

IL-17 family is a group of proinflammatory cytokines produced by activated memory T-cells. These cytokines play an important role in the development of cellular and humoral mechanisms of immunological responses lying at the basis of allergic disorders. The aim of this paper is to present the current knowledge on the role of interleukin 17 cytokine family in the pathogenesis of allergic disorders of the respiratory tract. IL-17A (as well as IL-17F) plays role in the development of airway hyperresponsiveness through activation of allergen-specific T-cells. Levels of IL-17A are elevated in sputum of asthmatic patients and correlate with airway hyperresponsiveness to methacholine. However, it remains fact, that the main effect of IL-17A in the pulmonary tract is recrutation of polymorphonuclear leukocytes, depending on CXC chemokine release from stromal cells. IL-17E evokes different immunological responses. This cytokine participates in the development of Th2-cell-dependent immunological response and the coexisting pathological tissue changes. These actions take place mainly through the induction of synthesis of the Th2 cell-derived cytokines (IL-4, IL-5, IL-13) and the development of eosinophilic inflammation. It is thought, that the character of the immunological response evoked by different cytokines of IL-17 family depends on the differences between the spatial structure of their fragments including disulfi de bridges and that these differences determine their receptor interactions and biological functions.
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Keywords

interleukin 17; cytokines; allergic diseseases; pulmonary tract

About this article
Title

The role of interleukin 17 cytokine family in inducing allergic inflammation in the pulmonary tract

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 4 (2006)

Pages

409-413

Published online

2006-09-08

Bibliographic record

Pneumonol Alergol Pol 2006;74(4):409-413.

Keywords

interleukin 17
cytokines
allergic diseseases
pulmonary tract

Authors

Aleksandra Semik-Orzech
Adam Barczyk
Władysław Pierzchała

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