open access

Vol 74, No 4 (2006)
ORIGINAL PAPERS
Published online: 2006-09-08
Submitted: 2013-02-22
Get Citation

Lack of correlation between exhaled nitric oxide (eNO) and clinical indicators of the disease activity and quality of life in mild and moderate asthmatics

Damian Tworek, Małgorzata Bocheńska-Marciniak, Maciej Kupczyk, Izabela Kupryś-Lipińska, Piotr Kuna
Pneumonol Alergol Pol 2006;74(4):391-395.

open access

Vol 74, No 4 (2006)
ORIGINAL PAPERS
Published online: 2006-09-08
Submitted: 2013-02-22

Abstract

The measurements of exhaled nitric oxide (eNO) are simple and useful method of assessment of inflammation in asthmatics’ airways. One of the causes of its limited application in clinical practice is a number of factors influencing the results of measurements.
The aim of the study was to determine the usefulness of eNO measurements in assessing the inflammation in a heterogeneous, in relation to atopic and smoking status, group of patients.
Materials and methods: 120 subjects suspected of having asthma participated in this study. During 2 weeks the patients noted daily asthma symptoms and daily use of rescue medication. After 14 days health related quality of life (HRQL) was determined by means of Asthma Quality of Life Questionnaire (AQLQ), eNO levels were measured and airways reversibility test was performed. Results: Preliminary diagnosis of asthma was confi rmed in 84 patients on the basis of positive result of airways reversibility test. Among them, 21 subjects (25%) were smokers and 60 (71.4%) were atopic. No correlation was found between eNO and daily asthma symptom score, daily use of rescue medication, percent of airway reversibility after β2-agonist and HRQL. Conclusion: eNO measurements in a heterogeneous, in relation to atopic and smoking status, group of patients are of limited value in clinical assessment of asthma activity.

Abstract

The measurements of exhaled nitric oxide (eNO) are simple and useful method of assessment of inflammation in asthmatics’ airways. One of the causes of its limited application in clinical practice is a number of factors influencing the results of measurements.
The aim of the study was to determine the usefulness of eNO measurements in assessing the inflammation in a heterogeneous, in relation to atopic and smoking status, group of patients.
Materials and methods: 120 subjects suspected of having asthma participated in this study. During 2 weeks the patients noted daily asthma symptoms and daily use of rescue medication. After 14 days health related quality of life (HRQL) was determined by means of Asthma Quality of Life Questionnaire (AQLQ), eNO levels were measured and airways reversibility test was performed. Results: Preliminary diagnosis of asthma was confi rmed in 84 patients on the basis of positive result of airways reversibility test. Among them, 21 subjects (25%) were smokers and 60 (71.4%) were atopic. No correlation was found between eNO and daily asthma symptom score, daily use of rescue medication, percent of airway reversibility after β2-agonist and HRQL. Conclusion: eNO measurements in a heterogeneous, in relation to atopic and smoking status, group of patients are of limited value in clinical assessment of asthma activity.
Get Citation

Keywords

exhaled nitric oxide; asthma; quality of life

About this article
Title

Lack of correlation between exhaled nitric oxide (eNO) and clinical indicators of the disease activity and quality of life in mild and moderate asthmatics

Journal

Advances in Respiratory Medicine

Issue

Vol 74, No 4 (2006)

Pages

391-395

Published online

2006-09-08

Bibliographic record

Pneumonol Alergol Pol 2006;74(4):391-395.

Keywords

exhaled nitric oxide
asthma
quality of life

Authors

Damian Tworek
Małgorzata Bocheńska-Marciniak
Maciej Kupczyk
Izabela Kupryś-Lipińska
Piotr Kuna

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl