open access

Vol 76, No 1 (2008)
REVIEWS
Published online: 2007-12-14
Submitted: 2013-02-22
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Role of ciclesonide in asthma therapy

Izabela Kupryś-Lipińska, Piotr Kuna
Pneumonol Alergol Pol 2008;76(1):37-43.

open access

Vol 76, No 1 (2008)
REVIEWS
Published online: 2007-12-14
Submitted: 2013-02-22

Abstract

Ciclesonide is a modern inhaled corticosteroid registered for asthma treatment. It is delivered as an inactive prodrug and undergoes conversion to an active metabolite in the lungs. Ciclesonide has been formulated as an aerosol solution in a metered dose inhaler with hydrofluoralkane which characterizes a high deposition rate over 50%. Lots of clinical trials show that ciclesonide is effective in asthma control in a wide range of doses from 40 do 1280 μg/day in a dose-dependent manner. It reduces the need for systemic corticosteroids. Due to the unique pharmacokinetics, ciclesonide has a favorable safety profile both in the low and in the high doses. It is recommended by GINA in every case when the glucocorticosteroids are indicated, as a drug with reduced local and systemic side effects. This article is a review of clinical trials on efficacy and safety of ciclesonide as the resume of authors’ clinical experience.

Abstract

Ciclesonide is a modern inhaled corticosteroid registered for asthma treatment. It is delivered as an inactive prodrug and undergoes conversion to an active metabolite in the lungs. Ciclesonide has been formulated as an aerosol solution in a metered dose inhaler with hydrofluoralkane which characterizes a high deposition rate over 50%. Lots of clinical trials show that ciclesonide is effective in asthma control in a wide range of doses from 40 do 1280 μg/day in a dose-dependent manner. It reduces the need for systemic corticosteroids. Due to the unique pharmacokinetics, ciclesonide has a favorable safety profile both in the low and in the high doses. It is recommended by GINA in every case when the glucocorticosteroids are indicated, as a drug with reduced local and systemic side effects. This article is a review of clinical trials on efficacy and safety of ciclesonide as the resume of authors’ clinical experience.
Get Citation

Keywords

asthma control; ciclesonide; efficacy; safety

About this article
Title

Role of ciclesonide in asthma therapy

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 1 (2008)

Pages

37-43

Published online

2007-12-14

Bibliographic record

Pneumonol Alergol Pol 2008;76(1):37-43.

Keywords

asthma control
ciclesonide
efficacy
safety

Authors

Izabela Kupryś-Lipińska
Piotr Kuna

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