open access
Safety of sputum induction in interstitial lung disease
open access
Abstract
Material and methods: We studied prospectively 59 patients (33 males, 26 females) with different ILD (36 - sarcoidosis, 16 - hypersensitivity pneumonitis, 7 - idiopathic pulmonary fibrosis). Sputum was induced by 4 sequential 5-minute inhalations of 5% saline solution and FEV1, FVC and SaO2 were measured at 5, 10, 15 and 20 minutes of induction.
Results: The procedure was well tolerated, and none of the patients experienced excessive bronchoconstriction, defined as a fall in FEV1 of ≥ 20%. Nine patients (15%) had a fall in FEV1 of ≥ 10% from the baseline; a drop in FVC of ≥ 10% from the baseline was observed in 10 subjects. The mean (SD) maximum per cent fall in FEV1 was 6,3 ± 4,4%, and in FVC - 6,4 ± ± 4,6%. The maximum per cent fall in FEV1 did not correlate with baseline FEV1% predicted (r = –0,099). SaO2 was measured in 42 patients. There was a very small fall in SaO2 at 5, 10, 15 and 20 minutes of induction, although statistically significant (baseline SaO2 = 96,7 ± 1,9% vs 95,8 ± 2,4%, p = 0,002; vs 96,1 ± 2,2%, p = 0,0114; vs 95,7 ± 2,4%, p = 0,0016; vs 95,9 ± 2,0%; p = 0,0038, respectively). No significant relationship was found between fall in FEV1, FVC or SaO2 after induction and diagnosis or smoking history.
Conclusion: Sputum induction is safe and well tolerated in patients with ILD.
Abstract
Material and methods: We studied prospectively 59 patients (33 males, 26 females) with different ILD (36 - sarcoidosis, 16 - hypersensitivity pneumonitis, 7 - idiopathic pulmonary fibrosis). Sputum was induced by 4 sequential 5-minute inhalations of 5% saline solution and FEV1, FVC and SaO2 were measured at 5, 10, 15 and 20 minutes of induction.
Results: The procedure was well tolerated, and none of the patients experienced excessive bronchoconstriction, defined as a fall in FEV1 of ≥ 20%. Nine patients (15%) had a fall in FEV1 of ≥ 10% from the baseline; a drop in FVC of ≥ 10% from the baseline was observed in 10 subjects. The mean (SD) maximum per cent fall in FEV1 was 6,3 ± 4,4%, and in FVC - 6,4 ± ± 4,6%. The maximum per cent fall in FEV1 did not correlate with baseline FEV1% predicted (r = –0,099). SaO2 was measured in 42 patients. There was a very small fall in SaO2 at 5, 10, 15 and 20 minutes of induction, although statistically significant (baseline SaO2 = 96,7 ± 1,9% vs 95,8 ± 2,4%, p = 0,002; vs 96,1 ± 2,2%, p = 0,0114; vs 95,7 ± 2,4%, p = 0,0016; vs 95,9 ± 2,0%; p = 0,0038, respectively). No significant relationship was found between fall in FEV1, FVC or SaO2 after induction and diagnosis or smoking history.
Conclusion: Sputum induction is safe and well tolerated in patients with ILD.
Keywords
induced sputum; safety; sarcoidosis; hypersensitivity pneumonitis; idiopathic pulmonary fibrosis


Title
Safety of sputum induction in interstitial lung disease
Journal
Advances in Respiratory Medicine
Issue
Pages
11-18
Published online
2007-12-14
Bibliographic record
Pneumonol Alergol Pol 2008;76(1):11-18.
Keywords
induced sputum
safety
sarcoidosis
hypersensitivity pneumonitis
idiopathic pulmonary fibrosis
Authors
Małgorzata Sobiecka
Jan Kuś