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open access

Vol 76, No 5 (2008)
Review paper
Published online: 2008-09-17
Submitted: 2013-02-22
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Aspirin and other nonsteroidal anti-inflammatory drugs hypersensitivity - mechanisms, diagnostics and treatment

Maciej Kupczyk, Piotr Kuna
Pneumonol Alergol Pol 2008;76(5):366-377.

open access

Vol 76, No 5 (2008)
REVIEWS
Published online: 2008-09-17
Submitted: 2013-02-22

Abstract

Aspirin hypersensitivity syndrome includes several symptoms from the respiratory tract, skin and digestive system triggered by ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. Asthmatic attacks precipitated by aspirin or other nonsteroidal anti-inflammatory drugs occur in about 10% of all asthmatic patients. In subjects with aspirin hypersensitivity disruption of synthesis of prostaglandin E2 (PGE2) and overproduction of cysteinyl leukotrienes (Cys-LT) seem to be crucial in the pathogenesis of bronchial symptoms. Double blind, placebo controlled challenges are regarded as a gold standard in the diagnosis of aspirin hypersensitivity.

Abstract

Aspirin hypersensitivity syndrome includes several symptoms from the respiratory tract, skin and digestive system triggered by ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. Asthmatic attacks precipitated by aspirin or other nonsteroidal anti-inflammatory drugs occur in about 10% of all asthmatic patients. In subjects with aspirin hypersensitivity disruption of synthesis of prostaglandin E2 (PGE2) and overproduction of cysteinyl leukotrienes (Cys-LT) seem to be crucial in the pathogenesis of bronchial symptoms. Double blind, placebo controlled challenges are regarded as a gold standard in the diagnosis of aspirin hypersensitivity.

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Keywords

aspirin; nonsteroidal anti-inflammatory drugs; aspirin-exacerbated respiratory disease; aspirin-induced asthma

About this article
Title

Aspirin and other nonsteroidal anti-inflammatory drugs hypersensitivity - mechanisms, diagnostics and treatment

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 5 (2008)

Article type

Review paper

Pages

366-377

Published online

2008-09-17

Bibliographic record

Pneumonol Alergol Pol 2008;76(5):366-377.

Keywords

aspirin
nonsteroidal anti-inflammatory drugs
aspirin-exacerbated respiratory disease
aspirin-induced asthma

Authors

Maciej Kupczyk
Piotr Kuna

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