Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Advances in Respiratory Medicine
MENU
Shortcuts Submit an article Guide for Authors Ahead Of Print Author statement Editorial Policy and Information for Authors Reviewers 2020

open access

Vol 76, No 5 (2008)
Review paper
Submitted: 2013-02-22
Published online: 2008-09-17
View PDF (Polish) Download PDF file
Get Citation

Aspirin and other nonsteroidal anti-inflammatory drugs hypersensitivity - mechanisms, diagnostics and treatment

Maciej Kupczyk, Piotr Kuna
Pneumonol Alergol Pol 2008;76(5):366-377.

open access

Vol 76, No 5 (2008)
REVIEWS
Submitted: 2013-02-22
Published online: 2008-09-17

Abstract

Aspirin hypersensitivity syndrome includes several symptoms from the respiratory tract, skin and digestive system triggered by ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. Asthmatic attacks precipitated by aspirin or other nonsteroidal anti-inflammatory drugs occur in about 10% of all asthmatic patients. In subjects with aspirin hypersensitivity disruption of synthesis of prostaglandin E2 (PGE2) and overproduction of cysteinyl leukotrienes (Cys-LT) seem to be crucial in the pathogenesis of bronchial symptoms. Double blind, placebo controlled challenges are regarded as a gold standard in the diagnosis of aspirin hypersensitivity.

Abstract

Aspirin hypersensitivity syndrome includes several symptoms from the respiratory tract, skin and digestive system triggered by ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. Asthmatic attacks precipitated by aspirin or other nonsteroidal anti-inflammatory drugs occur in about 10% of all asthmatic patients. In subjects with aspirin hypersensitivity disruption of synthesis of prostaglandin E2 (PGE2) and overproduction of cysteinyl leukotrienes (Cys-LT) seem to be crucial in the pathogenesis of bronchial symptoms. Double blind, placebo controlled challenges are regarded as a gold standard in the diagnosis of aspirin hypersensitivity.

Full Text:

View PDF (Polish) Download PDF file
Get Citation

Keywords

aspirin; nonsteroidal anti-inflammatory drugs; aspirin-exacerbated respiratory disease; aspirin-induced asthma

About this article
Title

Aspirin and other nonsteroidal anti-inflammatory drugs hypersensitivity - mechanisms, diagnostics and treatment

Journal

Advances in Respiratory Medicine

Issue

Vol 76, No 5 (2008)

Article type

Review paper

Pages

366-377

Published online

2008-09-17

Bibliographic record

Pneumonol Alergol Pol 2008;76(5):366-377.

Keywords

aspirin
nonsteroidal anti-inflammatory drugs
aspirin-exacerbated respiratory disease
aspirin-induced asthma

Authors

Maciej Kupczyk
Piotr Kuna

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Pneumonologia i Alergologia Polska dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl