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Vol 77, No 2 (2009)
Review paper
Published online: 2009-03-16
Submitted: 2013-02-22
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Potential role of endothelin in patients with acute pulmonary embolism and chronic thromboembolic pulmonary hypertension

Justyna Pedowska-Włoszek, Maciej Kostrubiec, Piotr Pruszczyk
Pneumonol Alergol Pol 2009;77(2):159-165.

open access

Vol 77, No 2 (2009)
REVIEWS
Published online: 2009-03-16
Submitted: 2013-02-22

Abstract

Endothelins (ET), a family of three peptides of strong vasoconstrictive properties, participate in the regulation of vascular tone and blood flow. The synthesis and degradation of the ET predominantly take place in the pulmonary vasculature. Elevated plasma ET levels were reported in various forms of arterial pulmonary hypertension including chronic thromboembolic pulmonary hypertension (CTEPH). Moreover, clinical studies with nonselective ET receptor antagonist - bosentan reported improvement in functional class in patients with CTEPH. It has been suggested that endothelins may play an important role in acute pulmonary thromboembolism (APE). However, further studies are necessary to verify these observations. In the current paper we discuss a potential role of endothelins in CTEPH and APE.

Abstract

Endothelins (ET), a family of three peptides of strong vasoconstrictive properties, participate in the regulation of vascular tone and blood flow. The synthesis and degradation of the ET predominantly take place in the pulmonary vasculature. Elevated plasma ET levels were reported in various forms of arterial pulmonary hypertension including chronic thromboembolic pulmonary hypertension (CTEPH). Moreover, clinical studies with nonselective ET receptor antagonist - bosentan reported improvement in functional class in patients with CTEPH. It has been suggested that endothelins may play an important role in acute pulmonary thromboembolism (APE). However, further studies are necessary to verify these observations. In the current paper we discuss a potential role of endothelins in CTEPH and APE.

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Keywords

endothelins; acute pulmonary embolism; chronic thromboembolic hypertension

About this article
Title

Potential role of endothelin in patients with acute pulmonary embolism and chronic thromboembolic pulmonary hypertension

Journal

Advances in Respiratory Medicine

Issue

Vol 77, No 2 (2009)

Article type

Review paper

Pages

159-165

Published online

2009-03-16

Bibliographic record

Pneumonol Alergol Pol 2009;77(2):159-165.

Keywords

endothelins
acute pulmonary embolism
chronic thromboembolic hypertension

Authors

Justyna Pedowska-Włoszek
Maciej Kostrubiec
Piotr Pruszczyk

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