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Vol 78, No 1 (2010)
Research paper
Submitted: 2013-02-22
Published online: 2010-01-29
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Elevated serum NSE level in locally advanced and metastatic NSCLC predispose to better response to chemotherapy but worse survival

Monika Załęska, Monika Szturmowicz, Jacek Zych, Barbara Roszkowska-Śliż, Urszula Demkow, Renata Langfort, Kazimierz Roszkowski-Śliż
Pneumonol Alergol Pol 2010;78(1):14-20.

open access

Vol 78, No 1 (2010)
ORIGINAL PAPERS
Submitted: 2013-02-22
Published online: 2010-01-29

Abstract

The aim of the study was to evaluate the predictive and prognostic values of elevated serum levels of selected cancer markers (NSE, Cyfra 21-1, CEA, ferritin, free beta-hCG, LDH) in patients with inoperable non-small-cell lung cancer (NSCLC). We investigated a group of 79 patients (49 men and 30 women) with NSCLC. Multivariate regression analysis showed response in patients with NSE > 12.5 ng/ml (p = 0.002), good performance status (p = 0.007) and elderly patients (p = 0.005). However, elevated NSE adversely affected the prognosis. Median survival in patients with NSE < 12.5 ng/ml, 12.5-20.0 ng/ml and > 20.0 ng/ml was 13.3, 11.3 and 6.7 months, respectively (p = 0.004). The negative effect of elevated NSE was independent of the response category. Univariate regression analysis showed that the following factors had a significantly negative effect on the prognosis: performance status, stage IIIB or IV, weight loss of > 10%, NSE > 20 ng/ml, Cyfra 21-1 > 10 ng/ml, CEA > 3 ng/ml, ferritin ratio > 1 and LDH > 480 IU/l. Multivariate analysis showed an independent adverse prognostic effect of stage IIIB or IV and elevated ferritin.

Abstract

The aim of the study was to evaluate the predictive and prognostic values of elevated serum levels of selected cancer markers (NSE, Cyfra 21-1, CEA, ferritin, free beta-hCG, LDH) in patients with inoperable non-small-cell lung cancer (NSCLC). We investigated a group of 79 patients (49 men and 30 women) with NSCLC. Multivariate regression analysis showed response in patients with NSE > 12.5 ng/ml (p = 0.002), good performance status (p = 0.007) and elderly patients (p = 0.005). However, elevated NSE adversely affected the prognosis. Median survival in patients with NSE < 12.5 ng/ml, 12.5-20.0 ng/ml and > 20.0 ng/ml was 13.3, 11.3 and 6.7 months, respectively (p = 0.004). The negative effect of elevated NSE was independent of the response category. Univariate regression analysis showed that the following factors had a significantly negative effect on the prognosis: performance status, stage IIIB or IV, weight loss of > 10%, NSE > 20 ng/ml, Cyfra 21-1 > 10 ng/ml, CEA > 3 ng/ml, ferritin ratio > 1 and LDH > 480 IU/l. Multivariate analysis showed an independent adverse prognostic effect of stage IIIB or IV and elevated ferritin.

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Keywords

neuron specific enolase; non-small-cell lung cancer; prognosis; response to treatment

About this article
Title

Elevated serum NSE level in locally advanced and metastatic NSCLC predispose to better response to chemotherapy but worse survival

Journal

Advances in Respiratory Medicine

Issue

Vol 78, No 1 (2010)

Article type

Research paper

Pages

14-20

Published online

2010-01-29

Bibliographic record

Pneumonol Alergol Pol 2010;78(1):14-20.

Keywords

neuron specific enolase
non-small-cell lung cancer
prognosis
response to treatment

Authors

Monika Załęska
Monika Szturmowicz
Jacek Zych
Barbara Roszkowska-Śliż
Urszula Demkow
Renata Langfort
Kazimierz Roszkowski-Śliż

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