open access

Vol 79, No 2 (2011)
ORIGINAL PAPERS
Published online: 2011-02-24
Submitted: 2013-02-22

Coexistence of obstructive sleep apnea syndrome and chronic obstructive pulmonary disease

Anna Brzecka, Irena Porębska, Tomasz Dyła, Monika Kosacka, Renata Jankowska
Pneumonol Alergol Pol 2011;79(2):99-108.

open access

Vol 79, No 2 (2011)
ORIGINAL PAPERS
Published online: 2011-02-24
Submitted: 2013-02-22

Abstract


Introduction: Both obstructive sleep apnea (OSA) syndrome and chronic obstructive pulmonary disease (COPD) may lead to chronic alveolar hypoventilation. The coexistence of OSA syndrome and COPD has been named the overlap syndrome. The aim of the study was to elucidate the relationship between the severity of COPD and the occurrence of chronic alveolar hypoventilation in patients with OSA syndrome.
Material and methods: The material of the study consisted of 64 obese (BMI 40 ± 5.5 kg/m2) patients with OSA syndrome (AHI >15, mean 52 ± 23) and coexisting COPD (FEV1/FVC < 70%). The results of polysomnographic, spirometric and arterial blood gases studies have been evaluated.
Results: Chronic alveolar hypoventilation has been found in 67% of the patients: in 60.5% of patients in the spirometric stage II, in 85% of patients in the stage III and in all the patients in the stage IV of COPD. In the patients with chronic alveolar hypoventilation as compared with the remaining patiens there were: lower FVC (2.7 ± 0.8 L v. 3.6 ± 0.9 L; p < 0.001), FEV1 (1.7 ± 0.6 L v. 2.2 ± 0.5 L; p < 0.001) and mean SaO2 during obstructive sleep apneas and hypopneas (75 ± 10% v. 84 ± 5%; p < 0.001).
Conclusions: Chronic alveolar hypoventilation occurs in most of the obese patients with moderate and severe OSA syndrome and coexisting COPD, including most of the patients with moderately impaired ventilatory function. The occurrence of chronic alveolar hypoventilation in the course of the overlap syndrome is related to the restrictive ventilatory pattern and the lower mean and minimal SaO2 during obstructive sleep apneas and hypopneas.
Pneumonol. Alergol. Pol. 2011; 79, 2: 99-108

Keywords

obstructive sleep apnea syndrome; chronic obstructive pulmonary disease; overlap syndrome

About this article
Title

Coexistence of obstructive sleep apnea syndrome and chronic obstructive pulmonary disease

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 2 (2011)

Pages

99-108

Published online

2011-02-24

Bibliographic record

Pneumonol Alergol Pol 2011;79(2):99-108.

Keywords

obstructive sleep apnea syndrome
chronic obstructive pulmonary disease
overlap syndrome

Authors

Anna Brzecka
Irena Porębska
Tomasz Dyła
Monika Kosacka
Renata Jankowska

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