open access

Vol 79, No 4 (2011)
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Published online: 2011-06-15
Submitted: 2013-02-22
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Role of biomarkers in making the diagnosis of tuberculous pleurisy

Joanna Klimiuk, Rafał Krenke
Pneumonol Alergol Pol 2011;79(4):288-297.

open access

Vol 79, No 4 (2011)
REVIEWS
Published online: 2011-06-15
Submitted: 2013-02-22

Abstract

Although tuberculosis is one of the most common causes of pleural effusion, diagnosis of tuberculous pleuritis still remains a challenge. This is due to paucity of M. tuberculosis organisms in pleural effusion which results in a relatively low sensitivity of the routinely used diagnostic methods. Thus, different biomarkers in pleural effusion have been extensively studied in order to improve the diagnostic accuracy. Pleural fluid deaminase adenosine activity (ADA) and interferon gamma (IFN-g) concentration have been shown to be the most reliable and cost-effective markers of tuberculous pleurisy. Hence, these markers have been included in different diagnostic algorithms for patients suspected of tuberculous pleurisy. A high variability of the diagnostic performance and/or more advanced technical demands significantly limit the use of other relatively new diagnostic methods, such as nucleic acid amplification tests (NAATs) and IFN-g releasing assays (IGRAs). The article presents a current data on the potential use of different biomarkers in the diagnosis of tuberculous pleurisy.
Pneumonol. Alergol. Pol. 2011; 79, 4: 288–297

Abstract

Although tuberculosis is one of the most common causes of pleural effusion, diagnosis of tuberculous pleuritis still remains a challenge. This is due to paucity of M. tuberculosis organisms in pleural effusion which results in a relatively low sensitivity of the routinely used diagnostic methods. Thus, different biomarkers in pleural effusion have been extensively studied in order to improve the diagnostic accuracy. Pleural fluid deaminase adenosine activity (ADA) and interferon gamma (IFN-g) concentration have been shown to be the most reliable and cost-effective markers of tuberculous pleurisy. Hence, these markers have been included in different diagnostic algorithms for patients suspected of tuberculous pleurisy. A high variability of the diagnostic performance and/or more advanced technical demands significantly limit the use of other relatively new diagnostic methods, such as nucleic acid amplification tests (NAATs) and IFN-g releasing assays (IGRAs). The article presents a current data on the potential use of different biomarkers in the diagnosis of tuberculous pleurisy.
Pneumonol. Alergol. Pol. 2011; 79, 4: 288–297
Get Citation

Keywords

tuberculous pleurisy; tuberculous pleural effusion; biomarkers; adenosine deaminase (ADA); interferon gamma (IFN-g); interferon gamma releasing assays (IGRAs); interleukin 12 (IL-12); interferon-inducible protein 10 (IP-10)

About this article
Title

Role of biomarkers in making the diagnosis of tuberculous pleurisy

Journal

Advances in Respiratory Medicine

Issue

Vol 79, No 4 (2011)

Pages

288-297

Published online

2011-06-15

Bibliographic record

Pneumonol Alergol Pol 2011;79(4):288-297.

Keywords

tuberculous pleurisy
tuberculous pleural effusion
biomarkers
adenosine deaminase (ADA)
interferon gamma (IFN-g)
interferon gamma releasing assays (IGRAs)
interleukin 12 (IL-12)
interferon-inducible protein 10 (IP-10)

Authors

Joanna Klimiuk
Rafał Krenke

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