open access

Vol 80, No 1 (2012)
ORIGINAL PAPERS
Published online: 2011-12-21
Submitted: 2013-02-22
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The principles of diagnosis of Churg-Strauss syndrome, in the authors’ experience

Justyna Fijołek, Elżbieta Wiatr, Dariusz Gawryluk, Renata Langfort, Jarosław Kober, Dorota Piotrowska-Kownacka, Karina Oniszh
Pneumonol Alergol Pol 2012;80(1):20-28.

open access

Vol 80, No 1 (2012)
ORIGINAL PAPERS
Published online: 2011-12-21
Submitted: 2013-02-22

Abstract


Introduction: The diagnosis of Churg-Strauss syndrome (CSS) is difficult because pathological criteria are present in minority of patients and in advanced stages. Several centers elaborated criteria which allowed to suspect CSS in patients with asthma, hypereosinophilia and clinical manifestations consistent with systemic vasculitis with or without histologic evidence. The aim of the study is the presentation of the basis of CSS diagnosis in our material.
Material and methods: The analysis included 38 patients. Blood and biochemical analysis, radiological examinations of the chest and sinuses, echocardiography were performed in all patients. In 22/23 patients with cardiac symptoms magnetic resonance of the heart was performed. In two patients mediastinoscopy was performed, in 4 — laparotomy.
Results: Only in 13/38 patients vasculitis was histologically proven, in the rest the diagnosis was established mainly on clinical ground. In 23 patients the diagnosis was established on the clinical cardiac symptoms — in all of them the cardiac involvement was confirmed by magnetic resonance. In 9 cases skin leasions were cause of further diagnostic procedures, 6 patients presented gastrointestinal symptoms, in 15 — paralysis of peroneal nerve was observed, and 1 patient had polyneuropathy and symptoms of central nervous system.
Conclusions: The diagnosis of CSS in our material was established mainly on clinical ground, because histologic material was difficult to obtain (it needs invasive procedures). Only in 13 from 38 patients vasculitis was histologically proven. The presence of asthma, sinusitis associated with peripheral eosinophilia and organ symptoms suggesting a vasculitis could support the diagnosis, without histologic evidence.
Pneumonol. Alergol. Pol. 2012; 80, 1: 20–28

Abstract


Introduction: The diagnosis of Churg-Strauss syndrome (CSS) is difficult because pathological criteria are present in minority of patients and in advanced stages. Several centers elaborated criteria which allowed to suspect CSS in patients with asthma, hypereosinophilia and clinical manifestations consistent with systemic vasculitis with or without histologic evidence. The aim of the study is the presentation of the basis of CSS diagnosis in our material.
Material and methods: The analysis included 38 patients. Blood and biochemical analysis, radiological examinations of the chest and sinuses, echocardiography were performed in all patients. In 22/23 patients with cardiac symptoms magnetic resonance of the heart was performed. In two patients mediastinoscopy was performed, in 4 — laparotomy.
Results: Only in 13/38 patients vasculitis was histologically proven, in the rest the diagnosis was established mainly on clinical ground. In 23 patients the diagnosis was established on the clinical cardiac symptoms — in all of them the cardiac involvement was confirmed by magnetic resonance. In 9 cases skin leasions were cause of further diagnostic procedures, 6 patients presented gastrointestinal symptoms, in 15 — paralysis of peroneal nerve was observed, and 1 patient had polyneuropathy and symptoms of central nervous system.
Conclusions: The diagnosis of CSS in our material was established mainly on clinical ground, because histologic material was difficult to obtain (it needs invasive procedures). Only in 13 from 38 patients vasculitis was histologically proven. The presence of asthma, sinusitis associated with peripheral eosinophilia and organ symptoms suggesting a vasculitis could support the diagnosis, without histologic evidence.
Pneumonol. Alergol. Pol. 2012; 80, 1: 20–28
Get Citation

Keywords

Churg-Strauss syndrome; clinical manifestations; principles of diagnosis.

About this article
Title

The principles of diagnosis of Churg-Strauss syndrome, in the authors’ experience

Journal

Advances in Respiratory Medicine

Issue

Vol 80, No 1 (2012)

Pages

20-28

Published online

2011-12-21

Bibliographic record

Pneumonol Alergol Pol 2012;80(1):20-28.

Keywords

Churg-Strauss syndrome
clinical manifestations
principles of diagnosis.

Authors

Justyna Fijołek
Elżbieta Wiatr
Dariusz Gawryluk
Renata Langfort
Jarosław Kober
Dorota Piotrowska-Kownacka
Karina Oniszh

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