open access

Vol 81, No 1 (2013)
ORIGINAL PAPERS
Published online: 2012-12-13
Submitted: 2013-02-22
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Clara Cell protein and myeloperoxidase levels in serum of subjects after exposure to fire smoke

Anna Krakowiak, Tadeusz Hałatek, Ewa Nowakowska-Świrta, Renata Winnicka, Piotr Politański, Sylwia Świderska-Kiełbik
Pneumonol Alergol Pol 2013;81(1):16-23.

open access

Vol 81, No 1 (2013)
ORIGINAL PAPERS
Published online: 2012-12-13
Submitted: 2013-02-22

Abstract

Introduction. Fire smoke inhalation is a well-recognized aetiological factor of airway injuries. The objective of this study was evaluation of Clara cell protein (CC16) and myeloperoxidase (MPO) concentrations in serum of patients after exposure to uncontrolled fire smoke.
Methods. The study group consisted of 40 consecutive patients admitted to the Toxicology Unit after exposure to fire smoke. CC16 and MPO concentrations in their serum samples was measured on the day of admission to hospital and rechecked at the 2nd day and on the day of discharge. Patients also underwent routine toxicological diagnostic procedures applied in case of exposures, such as carboxyhaemoglobin (COHb) levels and blood lactate and urinary thiocyanate concentrations. The same diagnostic tests were performed in the control group consisting of 10 healthy subjects not exposed to fire smoke.
Results. The average concentration of CC16 in the serum of subjects exposed to toxic factors was significantly higher at the day of admission in comparison with the respective values recorded on the 2nd day and on the day of discharge. The mean level of CC16 in the serum of the exposed group was also significantly higher than that in the control group. Tests for MPO concentrations in the serum did not reveal any significant changes in patients exposed to fire smoke.
Conclusions. As indicated, acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects.

Abstract

Introduction. Fire smoke inhalation is a well-recognized aetiological factor of airway injuries. The objective of this study was evaluation of Clara cell protein (CC16) and myeloperoxidase (MPO) concentrations in serum of patients after exposure to uncontrolled fire smoke.
Methods. The study group consisted of 40 consecutive patients admitted to the Toxicology Unit after exposure to fire smoke. CC16 and MPO concentrations in their serum samples was measured on the day of admission to hospital and rechecked at the 2nd day and on the day of discharge. Patients also underwent routine toxicological diagnostic procedures applied in case of exposures, such as carboxyhaemoglobin (COHb) levels and blood lactate and urinary thiocyanate concentrations. The same diagnostic tests were performed in the control group consisting of 10 healthy subjects not exposed to fire smoke.
Results. The average concentration of CC16 in the serum of subjects exposed to toxic factors was significantly higher at the day of admission in comparison with the respective values recorded on the 2nd day and on the day of discharge. The mean level of CC16 in the serum of the exposed group was also significantly higher than that in the control group. Tests for MPO concentrations in the serum did not reveal any significant changes in patients exposed to fire smoke.
Conclusions. As indicated, acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects.
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Keywords

Clara cell protein; myeloperoxidase; lung toxicity; fire; firefighters

About this article
Title

Clara Cell protein and myeloperoxidase levels in serum of subjects after exposure to fire smoke

Journal

Advances in Respiratory Medicine

Issue

Vol 81, No 1 (2013)

Pages

16-23

Published online

2012-12-13

Bibliographic record

Pneumonol Alergol Pol 2013;81(1):16-23.

Keywords

Clara cell protein
myeloperoxidase
lung toxicity
fire
firefighters

Authors

Anna Krakowiak
Tadeusz Hałatek
Ewa Nowakowska-Świrta
Renata Winnicka
Piotr Politański
Sylwia Świderska-Kiełbik

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