Tom 12, Nr 1 (2017)
UCZYMY SIĘ!
Opublikowany online: 2017-03-09
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Kardioprotekcja — czy nie zapominamy o ochronie krążenia wieńcowego. Część I. Podstawy patofizjologiczne
Kardiol Inwazyjna 2017;12(1):15-20.
Streszczenie
Choroby układu sercowo-naczyniowego, a wśród nich choroba wieńcowa, od lat pozostają jedną z najczęstszych przyczyn zgonów na świecie. Podczas niedokrwienia reperfuzja jest jedyną metodą pozwalającą na zachowanie żywotności mięśnia sercowego. Niestety, już w latach 70. XX wieku wiadomo było, że do uszkodzenia miokardium dochodzi nie tylko w trakcie niedokrwienia, ale również w czasie reperfuzji. Publikowane są liczne prace omawiające patomechanizm powstawania uszkodzenia związanego z niedokrwieniem i reperfuzją. Większość autorów skupia się na zmianach zachodzących w miokardium, jednakże coraz częściej nacisk kładziony jest też na mikrokrążenie wieńcowe, które nie tylko jest „sprawcą”, ale powinniśmy myśleć o nim również jako o „ofierze” uszkodzenia związanego z niedokrwieniem i reperfuzją. W tej części artykułu chcemy zaprezentować podstawy patofizjologiczne takiego rozumowania.
Słowa kluczowe: miokardiumhartowaniemikrokrążenie wieńcowe
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