Tom 12, Nr 2 (2017)
UCZYMY SIĘ!
Opublikowany online: 2017-05-31
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Kardioprotekcja — czy nie zapominamy o ochronie krążenia wieńcowego. Część 2 — znaczenie kliniczne
Kardiol Inwazyjna 2017;12(2):3-8.
Streszczenie
Reperfuzja jest jedyną metodą pozwalającą na zachowanie żywotności miokardium w ostrej fazie zawału. Jednak niedługo po publikacji doniesień mówiących o skuteczności terapeutycznej takiego postępowania zaczęto podnosić temat uszkodzenia miokardium występującego również w trakcie reperfuzji, a nie tylko niedokrwienia. Od wielu lat prezentowane są prace oceniające wpływ różnych leków i interwencji mających na celu ochronę mięśnia sercowego w trakcie zarówno niedokrwienia, jak i reperfuzji. Jednak większość autorów skupia się zwykle na uszkodzeniu dotyczącym miokardium i metodach pozwalających na jego uniknięcie. Warto jednak pamiętać, że zmiany wywołanie niedokrwieniem i reperfuzją dotyczą również krążenia i mikrokrążenia wieńcowego, a zatem kardioprotekcja powinna obejmować również te ostatnie. W tej części artykułu przedstawiamy wyniki badań klinicznych i możliwości wykorzystania w praktyce klinicznej ochrony mikrokrążenia wieńcowego w trakcie niedokrwienia i reperfuzji.
Słowa kluczowe: miokardiumhartowaniemikrokrążenie wieńcowe
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