Tom 3, Supl. D (2023)
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Opublikowany online: 2024-02-16
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Skuteczne leczenie asciminibem chorego na przewlekłą białaczkę szpikową w fazie przewlekłej w szóstej linii leczenia
DOI: 10.5603/hemedu.98593
Streszczenie
Rozwój terapii celowanych w przewlekłej białaczce szpikowej (CML), w tym inhibitorów kinaz tyrozynowych (TKI) BCR/ABL1 trzech generacji oraz inhibitora STAMP, stanowił przełom w leczeniu chorych, umożliwiając poprawę wyników leczenia i wydłużenie czasu przeżycia chorych. Pozostał jednak problem leczenia chorych z niepowodzeniem lub nietolerancją leczenia TKI, szczególnie w trzeciej, czwartej i kolejnych liniach leczenia CML. W pracy przedstawiono przypadek 61-letniego chorego na CML w fazie przewlekłej leczonego asciminibem w szóstej linii leczenia. Po niepowodzeniu/nietolerancji leczenia imatynibem, dazatynibem, bosutynibem, nilotynibem i ponatynibem chory w trakcie leczenia asciminibem osiągnął odpowiedź na leczenie — całkowitą remisję cytogenetyczną oraz większą odpowiedź molekularną.
Słowa kluczowe: przewlekła białaczka szpikowaasciminibnietolerancja inhibitorów kinaz tyrozynowychniepowodzenie leczenia inhibitorem kinaz tyrozynowychkardiotoksyczność
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