Tom 2, Nr 3-4 (2022)
STANOWISKO EKSPERTÓW
Opublikowany online: 2023-03-06
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Mutacje genu IDH1 — stanowisko ekspertów
Hematologia - Edukacja 2022;2(3-4):113-124.
Streszczenie
Iwosydenib jest silnym — stosowanym doustnie — inhibitorem szlaku zależnego od IDH1. Przedkliniczne dowody wartości iwosydenibu zostały potwierdzone przez wyniki prospektywnych badań klinicznych u chorych na ostrą białaczkę szpikową i raka dróg żółciowych z mutacją w genie IDH1. Optymalne wykorzystanie iwosydenibu — podobnie do innych ukierunkowanych leków przeciwnowotworowych — zależy od sprawnej i dokładnej diagnostyki morfologicznej i molekularnej. Artykuł został przygotowany w celu przedstawienia obecnych metod oceny stanu genu IDH1 i naukowego uzasadnienia dla stosowania iwosydenibu w ostrej białaczce szpikowej oraz raku dróg żółciowych.
Słowa kluczowe: gen IDH1ostra białaczka szpikowarak dróg żółciowychleczenie ukierunkowane molekularnieiwosydenib
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