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Tom 9, Nr 3 (2018)
WYBRANE PROBLEMY KLINICZNE
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Galectin-3: a potential biomarker for diagnostics of heart failure

Dominika Neumann, Katarzyna Korzeniowska, Artur Cieślewicz, Jerzy Jankowski, Anna Jabłecka, Karolina Majewska
Forum Zaburzeń Metabolicznych 2018;9(3):126-131.

dostęp otwarty

Tom 9, Nr 3 (2018)
WYBRANE PROBLEMY KLINICZNE

Streszczenie

Heart failure is a dysfunction with varied ethology; one of possible causes is anticancer treatment with anthracyclines. Rapid diagnosis is important because the disease is associated with high mortality and morbidity. The only biomarkers fully approved for diagnostics of heart failure are natriuretic peptides. They are secreted by ventricular muscle cells in response to volume and pressure overload. However, their concentration can be influenced by other factors, such as age or gender. A potential marker, not affected by these issues might be galectin-3. Current studies showed that galectin can play particularly significant role in myocardial fibrosis and inflammation. Elevated galectin-3 concentration has been observed in such cardiovascular diseases as heart failure,  atherosclerosis, stroke and myocardial infarction. The review summarizes results of studies which indicate the role of galectin-3 in inducing fibrosis and cardiac remodelling (processes which influence disease progression and prognosis) and showed its potential diagnostic value.

Streszczenie

Heart failure is a dysfunction with varied ethology; one of possible causes is anticancer treatment with anthracyclines. Rapid diagnosis is important because the disease is associated with high mortality and morbidity. The only biomarkers fully approved for diagnostics of heart failure are natriuretic peptides. They are secreted by ventricular muscle cells in response to volume and pressure overload. However, their concentration can be influenced by other factors, such as age or gender. A potential marker, not affected by these issues might be galectin-3. Current studies showed that galectin can play particularly significant role in myocardial fibrosis and inflammation. Elevated galectin-3 concentration has been observed in such cardiovascular diseases as heart failure,  atherosclerosis, stroke and myocardial infarction. The review summarizes results of studies which indicate the role of galectin-3 in inducing fibrosis and cardiac remodelling (processes which influence disease progression and prognosis) and showed its potential diagnostic value.
Pobierz cytowanie

Słowa kluczowe

galectin-3, heart failure, biomarkers, cardiology, oncology

Informacje o artykule
Tytuł

Galectin-3: a potential biomarker for diagnostics of heart failure

Czasopismo

Forum Zaburzeń Metabolicznych

Numer

Tom 9, Nr 3 (2018)

Strony

126-131

Rekord bibliograficzny

Forum Zaburzeń Metabolicznych 2018;9(3):126-131.

Słowa kluczowe

galectin-3
heart failure
biomarkers
cardiology
oncology

Autorzy

Dominika Neumann
Katarzyna Korzeniowska
Artur Cieślewicz
Jerzy Jankowski
Anna Jabłecka
Karolina Majewska

Referencje (32)
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