Tom 7, Nr 4 (2016)
WYBRANE PROBLEMY KLINICZNE
Opublikowany online: 2017-01-30
Wyświetlenia strony
1343
Wyświetlenia/pobrania artykułu
3349
Modyfikacja stylu życia jako element prewencji raka piersi otyłej pacjentki
Forum Zaburzeń Metabolicznych 2016;7(4):162-169.
Streszczenie
Liczba zachorowań na nowotwor y złośliwe w P olsce w ciągu ostatnich 30 lat wzrosła ponad dwu krotnie. Wyniki badań wskazują, że otyło ść zwiększa prawdopodobieństwo zachorowania i zgonu z powodu nowotworu. Wymienia się wiele mechanizmów patogenetycznych tłumaczących to powiązanie. Nadmier nie nagromadzona tkanka tłuszczowa (zwłaszcza trzewna) jest miejscem toczącego się przewlekłego stanu zapalnego, który powoduje wahania stężeń insuliny , glukozy, wolnych kwasów tłuszczowych, adiponek - tyny, leptyny, insulinopodobnych czynników wzrostu, czynnika mar twicy nowotworów, interleukin (1, 6, 12, 23), czynnika wzrostu śródbłonka naczyniowego i innych. Czynniki te mogą stymulować wzrost i podziały komórek nowotworowych. W pracy przedstawiono przypadek kobiety z rozpoznanym przed dwoma laty wczesnym nowotworem piersi, która po zakończeniu leczenia onkologicznego trafiła do poradni za burzeń metabolicznych i nadciśnienia tętniczego z powodu otyłości.
Słowa kluczowe: otyłośćnowotworyrak piersi
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