open access

Vol 22, No 4 (2018)
REVIEW
Published online: 2018-05-30
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Coronary microcirculation dysfunction in patients with arterial hypertension

Adam Kern, Jerzy Górny, Martyna Zaleska, Olga Możeńska, Jacek Bil
DOI: 10.5603/AH.a2018.0003
·
Arterial Hypertension 2018;22(4):151-155.

open access

Vol 22, No 4 (2018)
REVIEW
Published online: 2018-05-30

Abstract

The number of articles regarding microcirculation dysfunction in the literature increases. One should bear them in
mind especially in case of patients, who declare typical angina, and in whom during coronary angiography we do
not reveal significant lesions in coronary arteries. Arterial hypertension is one of diseases, which may contribute to
microcirculation dysfunction and vessels remodeling. In this short review, we discuss possible mechanism of abovementioned
disturbances.

Abstract

The number of articles regarding microcirculation dysfunction in the literature increases. One should bear them in
mind especially in case of patients, who declare typical angina, and in whom during coronary angiography we do
not reveal significant lesions in coronary arteries. Arterial hypertension is one of diseases, which may contribute to
microcirculation dysfunction and vessels remodeling. In this short review, we discuss possible mechanism of abovementioned
disturbances.

Get Citation

Keywords

coronary microcirculation dysfunction; remodeling; arterial hypertension

About this article
Title

Coronary microcirculation dysfunction in patients with arterial hypertension

Journal

Arterial Hypertension

Issue

Vol 22, No 4 (2018)

Pages

151-155

Published online

2018-05-30

DOI

10.5603/AH.a2018.0003

Bibliographic record

Arterial Hypertension 2018;22(4):151-155.

Keywords

coronary microcirculation dysfunction
remodeling
arterial hypertension

Authors

Adam Kern
Jerzy Górny
Martyna Zaleska
Olga Możeńska
Jacek Bil

References (46)
  1. Mills KT, Bundy JD, Kelly TN, et al. Global Disparities of Hypertension Prevalence and Control: A Systematic Analysis of Population-Based Studies From 90 Countries. Circulation. 2016; 134(6): 441–450.
  2. Tykarski A, Narkiewicz K, Gaciong Z, et al. Guidelines for the Management of Hypertension. Arterial Hypertens. 2015; 19(2): 53–83.
  3. Lazzeroni D, Rimoldi O, Camici PG. From Left Ventricular Hypertrophy to Dysfunction and Failure. Circ J. 2016; 80(3): 555–564.
  4. Díez J, González A, López B, et al. Mechanisms of disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease. Nat Clin Pract Cardiovasc Med. 2005; 2(4): 209–216.
  5. Moreno MU, Eiros R, Gavira JJ, et al. The Hypertensive Myocardium: From Microscopic Lesions to Clinical Complications and Outcomes. Med Clin North Am. 2017; 101(1): 43–52.
  6. Cramariuc D, Gerdts E. Epidemiology of left ventricular hypertrophy in hypertension: implications for the clinic. Expert Rev Cardiovasc Ther. 2016; 14(8): 915–926.
  7. Labazi H, Trask AJ. Coronary microvascular disease as an early culprit in the pathophysiology of diabetes and metabolic syndrome. Pharmacol Res. 2017; 123: 114–121.
  8. Matrougui K, Lévy B, Henrion D. Tissue angiotensin II and endothelin-1 modulate differently the response to flow in mesenteric resistance arteries of normotensive and spontaneously hypertensive rats. Br J Pharmacol. 2000; 130(3): 521–526.
  9. Uematsu M, Ohara Y, Navas JP, et al. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol. 1995; 269(6 Pt 1): C1371–C1378.
  10. Malek A, Izumo S. Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol. 1992; 263(2 Pt 1): C389–C396.
  11. Kassan M, Choi SK, Galán M, et al. Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes. 2013; 62(6): 2078–2087.
  12. Wynne BM, Labazi H, Tostes RC, et al. Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. Pharmacol Res. 2012; 65(1): 41–47.
  13. Toque HA, Nunes KP, Yao L, et al. Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function. PLoS One. 2013; 8(8): e72277.
  14. Kelm M, Strauer B. Coronary flow reserve measurements in hypertension. Med Clin North Am. 2004; 88(1): 99–113.
  15. Duprez DA. Role of the renin-angiotensin-aldosterone system in vascular remodeling and inflammation: a clinical review. J Hypertens. 2006; 24(6): 983–991.
  16. Schiffrin EL. Vascular remodeling in hypertension: mechanisms and treatment. Hypertension. 2012; 59(2): 367–374.
  17. Intengan H, Schiffrin E. Vascular Remodeling in Hypertension. Hypertension. 2001; 38(3): 581–587.
  18. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med. 2007; 356(8): 830–840.
  19. Spoladore R, Fisicaro A, Faccini A, et al. Coronary microvascular dysfunction in primary cardiomyopathies. Heart. 2014; 100(10): 806–813.
  20. Rudic RD, Shesely EG, Maeda N, et al. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest. 1998; 101(4): 731–736.
  21. Myers PR, Tanner MA. Vascular Endothelial Cell Regulation of Extracellular Matrix Collagen : Role of Nitric Oxide. Arterioscler Thromb Vasc Biol. 1998; 18(5): 717–722.
  22. Hong Z, Reeves KJ, Sun Z, et al. Vascular smooth muscle cell stiffness and adhesion to collagen I modified by vasoactive agonists. PLoS One. 2015; 10(3): e0119533.
  23. Numaguchi K, Egashira K, Takemoto M, et al. Chronic Inhibition of Nitric Oxide Synthesis Causes Coronary Microvascular Remodeling in Rats. Hypertension. 1995; 26(6): 957–962.
  24. Quintana-Villamandos B, Arnalich-Montiel A, Arribas S, et al. Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats. Hypertens Res. 2016; 39(10): 692–700.
  25. Quintana-Villamandos B, González MC, Delgado-Martos MJ, et al. Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress. Eur J Pharmacol. 2016; 791: 502–509.
  26. Toque HA, Nunes KP, Rojas M, et al. Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension. Front Immunol. 2013; 4: 219.
  27. Virdis A, Neves MF, Amiri F, et al. Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. J Hypertens. 2004; 22(3): 535–542.
  28. Cho YE, Basu A, Dai A, et al. Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice. Am J Physiol Cell Physiol. 2013; 305(10): C1033–C1040.
  29. Wang C, Luo Z, Kohan D, et al. Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease. Hypertension. 2015; 65(5): 1055–1063.
  30. Staiculescu MC, Foote C, Meininger GA, et al. The role of reactive oxygen species in microvascular remodeling. Int J Mol Sci. 2014; 15(12): 23792–23835.
  31. Wynne BM, Chiao CW, Webb RC. Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1. J Am Soc Hypertens. 2009; 3(2): 84–95.
  32. Cousin M, Custaud MA, Baron-Menguy C, et al. Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries. Hypertension. 2010; 55(1): 109–115.
  33. Paulis L, Becker STR, Lucht K, et al. Direct angiotensin II type 2 receptor stimulation in Nω-nitro-L-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling. Hypertension. 2012; 59(2): 485–492.
  34. Santos RAS, Ferreira AJ, Verano-Braga T, et al. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system. J Endocrinol. 2013; 216(2): R1–R17.
  35. Zhang Z, Chen L, Zhong J, et al. ACE2/Ang-(1-7) signaling and vascular remodeling. Sci China Life Sci. 2014; 57(8): 802–808.
  36. Sachidanandam K, Hutchinson JR, Elgebaly MM, et al. Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1. Am J Physiol Regul Integr Comp Physiol. 2009; 296(4): R952–R959.
  37. Böhm F, Pernow J. The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. Cardiovasc Res. 2007; 76(1): 8–18.
  38. Pu Q, Neves MF, Virdis A, et al. Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension. 2003; 42(1): 49–55.
  39. Sachidanandam K, Portik-Dobos V, Kelly-Cobbs AI, et al. Dual endothelin receptor antagonism prevents remodeling of resistance arteries in diabetes. Can J Physiol Pharmacol. 2010; 88(6): 616–621.
  40. Schmidt AM, Yan SD, Wautier JL, et al. Activation of Receptor for Advanced Glycation End Products : A Mechanism for Chronic Vascular Dysfunction in Diabetic Vasculopathy and Atherosclerosis. Circ Res. 1999; 84(5): 489–497.
  41. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens. 2003; 21(1): 3–12.
  42. Liu Yu, Yu M, Zhang Le, et al. Soluble receptor for advanced glycation end products mitigates vascular dysfunction in spontaneously hypertensive rats. Mol Cell Biochem. 2016; 419(1-2): 165–176.
  43. De Ciuceis C, Amiri F, Brassard P, et al. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arterioscler Thromb Vasc Biol. 2005; 25(10): 2106–2113.
  44. Guzik TJ, Hoch NE, Brown KA, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007; 204(10): 2449–2460.
  45. Ogawa A, Firth AL, Yao W, et al. Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2008; 295(4): L648–L657.
  46. Hoeth M, Hofer-Warbinek R, Schmid JA. The Transcription Factor NF- B and the Regulation of Vascular Cell Function. Arterioscler Thromb Vasc Biol. 2000; 20(11): e83–e88.

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