open access

Vol 15, No 6 (2010)
Review
Published online: 2010-11-01
Submitted: 2010-06-21
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A review on gold nanoparticles radiosensitization effect in radiation therapy of cancer

Asghar Mesbahi
DOI: 10.1016/j.rpor.2010.09.001
·
Rep Pract Oncol Radiother 2010;15(6):176-180.

open access

Vol 15, No 6 (2010)
Review
Published online: 2010-11-01
Submitted: 2010-06-21

Abstract

In the recent years, application of nanoparticles in diagnosis and treatment of cancer has been the issue of extensive research. Among these studies some have focused on the dose enhancement effect of gold nanoparticles (GNPs) in radiation therapy of cancer. On the other hand, some studies indicated energy dependency of dose enhancement effect, and the others have studied the GNP size effect in association with photon energy. However, in some aspects of GNP-based radiotherapy the results of recent studies do not seem very conclusive in spite of relative agreement on the basic physical interaction of photoelectric between GNPs and low energy photons. The main idea behind the GNP dose enhancement in some studies is not able to explain the results especially in recent investigation on cell lines and animal models radiation therapy using GNPs. In the present article the results of the available reports and articles were analyzed and compared and the final status of the GNP-RT was discussed.

Abstract

In the recent years, application of nanoparticles in diagnosis and treatment of cancer has been the issue of extensive research. Among these studies some have focused on the dose enhancement effect of gold nanoparticles (GNPs) in radiation therapy of cancer. On the other hand, some studies indicated energy dependency of dose enhancement effect, and the others have studied the GNP size effect in association with photon energy. However, in some aspects of GNP-based radiotherapy the results of recent studies do not seem very conclusive in spite of relative agreement on the basic physical interaction of photoelectric between GNPs and low energy photons. The main idea behind the GNP dose enhancement in some studies is not able to explain the results especially in recent investigation on cell lines and animal models radiation therapy using GNPs. In the present article the results of the available reports and articles were analyzed and compared and the final status of the GNP-RT was discussed.

Get Citation

Keywords

Gold nanoparticle; Radiation therapy; Monte Carlo method; Dose enhancement effect

About this article
Title

A review on gold nanoparticles radiosensitization effect in radiation therapy of cancer

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 15, No 6 (2010)

Pages

176-180

Published online

2010-11-01

DOI

10.1016/j.rpor.2010.09.001

Bibliographic record

Rep Pract Oncol Radiother 2010;15(6):176-180.

Keywords

Gold nanoparticle
Radiation therapy
Monte Carlo method
Dose enhancement effect

Authors

Asghar Mesbahi

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