open access

Vol 14, No 3 (2009)
Untitled
Published online: 2009-05-01
Submitted: 2009-05-11
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Whole body MR in patients with multiple myeloma

Alina PIEKAREK, Piotr SOSNOWSKI, Adam NOWICKI, Mieczysław KOMARNICKI
DOI: 10.1016/S1507-1367(10)60098-3
·
Rep Pract Oncol Radiother 2009;14(3):80-84.

open access

Vol 14, No 3 (2009)
Untitled
Published online: 2009-05-01
Submitted: 2009-05-11

Abstract

Background

Multiple myeloma is a cancer of plasma cells which leads to bone marrow infiltration.

Aim

Whole-body MR is the most sensitive imaging method available to detect multiple myeloma lesions.

Material and Methods

MR scans were performed in 100 patients with multiple myeloma who were receiving treatment in the Haematology Clinic in Poznań in the years 2005–2006. Whole-body MR scans were performed with general coil 1.0 T in STIR sequences and T1 sequences, in coronal and sagittal planes with scanning area covering the head, neck, trunk and the limbs (FOV for specific regions was 36–48 cm). The bone lesions were classified as focal (monofocal/multifocal lesions), in-filtrative, mixed and “salt and pepper” type. Depending on the size of the lesions the patients were included in one of three groups according to Salmon-Durie Plus classification.

Results

Four main types of multiple myeloma were distinguished based on MR scans: focal (48 patients; monofocal in 10 patients), infiltrative (17 patients), mixed type (19 patients) and “salt and pepper” type (4 patients). The remaining 12 patients had no multiple myeloma lesions in the bone marrow. Additionally, in 18% of patients a soft tissue mass could be observed. According to Salmon-Durie Plus categorisation 27 subjects were classified as having stage I, 16 patients stage and 57 patients stage III disease. In 12% of patients MR data changed the disease staging.

Conclusions

WB MR is a sensitive and effective diagnostic method with an important impact on staging and further treatment of multiple myeloma.

Abstract

Background

Multiple myeloma is a cancer of plasma cells which leads to bone marrow infiltration.

Aim

Whole-body MR is the most sensitive imaging method available to detect multiple myeloma lesions.

Material and Methods

MR scans were performed in 100 patients with multiple myeloma who were receiving treatment in the Haematology Clinic in Poznań in the years 2005–2006. Whole-body MR scans were performed with general coil 1.0 T in STIR sequences and T1 sequences, in coronal and sagittal planes with scanning area covering the head, neck, trunk and the limbs (FOV for specific regions was 36–48 cm). The bone lesions were classified as focal (monofocal/multifocal lesions), in-filtrative, mixed and “salt and pepper” type. Depending on the size of the lesions the patients were included in one of three groups according to Salmon-Durie Plus classification.

Results

Four main types of multiple myeloma were distinguished based on MR scans: focal (48 patients; monofocal in 10 patients), infiltrative (17 patients), mixed type (19 patients) and “salt and pepper” type (4 patients). The remaining 12 patients had no multiple myeloma lesions in the bone marrow. Additionally, in 18% of patients a soft tissue mass could be observed. According to Salmon-Durie Plus categorisation 27 subjects were classified as having stage I, 16 patients stage and 57 patients stage III disease. In 12% of patients MR data changed the disease staging.

Conclusions

WB MR is a sensitive and effective diagnostic method with an important impact on staging and further treatment of multiple myeloma.

Get Citation

Keywords

whole-body MR (WB MR); multiple myeloma (MM); Salmon-Durie Plus (S-D Plus)

About this article
Title

Whole body MR in patients with multiple myeloma

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 14, No 3 (2009)

Pages

80-84

Published online

2009-05-01

DOI

10.1016/S1507-1367(10)60098-3

Bibliographic record

Rep Pract Oncol Radiother 2009;14(3):80-84.

Keywords

whole-body MR (WB MR)
multiple myeloma (MM)
Salmon-Durie Plus (S-D Plus)

Authors

Alina PIEKAREK
Piotr SOSNOWSKI
Adam NOWICKI
Mieczysław KOMARNICKI

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