open access

Vol 12, No 5 (2007)
Untitled
Published online: 2007-09-01
Submitted: 2007-01-04
Get Citation

Hyperthermia – description of a method and a review of clinical applications

Adam Chicheł, Janusz Skowronek, Magda Kubaszewska, Marek Kanikowski
DOI: 10.1016/S1507-1367(10)60065-X
·
Rep Pract Oncol Radiother 2007;12(5):267-275.

open access

Vol 12, No 5 (2007)
Untitled
Published online: 2007-09-01
Submitted: 2007-01-04

Abstract

The aim of this paper is to give a concise description of hyperthermia and a brief review of its clinical applications. Hyperthermia (HT, thermal therapy) is thought to be one of the cancer therapies and is considered to be an artificial way of increasing the body tissue temperature by delivering heat obtained from external sources to destroy cancerous cells or prevent their further growth. The first principles of hyperthermic biology are presented. The phenomena of thermotolerance and radiosensitization are briefly described, as well as the concept of thermal dose delivered to the tissues.

Three main clinical applications of HT are presented. They include local, regional or part-body HT and whole-body HT that deliver heat to localized, advanced or deep-seated and disseminated malignancies, respectively, depending on location, depth and staging of the tumour. Energies used to apply heat to the tumour include microwaves, radiofrequency energy, ultrasound, infrared radiators and different kinds of hot sources (hot water, ferromagnetic seeds, nanoparticles, resistive implants). General indications for each HT subtype and possible combinations of HT with other cancer treatment modalities are presented.

Substantially, HT is used as an adjuvant therapy and in such a role it is being evaluated in many clinical randomized trials throughout the scientific medical centres. Their first preliminary results are already available, but still time is needed to produce firm conclusions and strict indications for hyperthermia treatment.

Abstract

The aim of this paper is to give a concise description of hyperthermia and a brief review of its clinical applications. Hyperthermia (HT, thermal therapy) is thought to be one of the cancer therapies and is considered to be an artificial way of increasing the body tissue temperature by delivering heat obtained from external sources to destroy cancerous cells or prevent their further growth. The first principles of hyperthermic biology are presented. The phenomena of thermotolerance and radiosensitization are briefly described, as well as the concept of thermal dose delivered to the tissues.

Three main clinical applications of HT are presented. They include local, regional or part-body HT and whole-body HT that deliver heat to localized, advanced or deep-seated and disseminated malignancies, respectively, depending on location, depth and staging of the tumour. Energies used to apply heat to the tumour include microwaves, radiofrequency energy, ultrasound, infrared radiators and different kinds of hot sources (hot water, ferromagnetic seeds, nanoparticles, resistive implants). General indications for each HT subtype and possible combinations of HT with other cancer treatment modalities are presented.

Substantially, HT is used as an adjuvant therapy and in such a role it is being evaluated in many clinical randomized trials throughout the scientific medical centres. Their first preliminary results are already available, but still time is needed to produce firm conclusions and strict indications for hyperthermia treatment.

Get Citation

Keywords

hyperthermia; cancer; method of treatment; clinical applications; heating techniques

About this article
Title

Hyperthermia – description of a method and a review of clinical applications

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 12, No 5 (2007)

Pages

267-275

Published online

2007-09-01

DOI

10.1016/S1507-1367(10)60065-X

Bibliographic record

Rep Pract Oncol Radiother 2007;12(5):267-275.

Keywords

hyperthermia
cancer
method of treatment
clinical applications
heating techniques

Authors

Adam Chicheł
Janusz Skowronek
Magda Kubaszewska
Marek Kanikowski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: journals@viamedica.pl