open access

Vol 14, No 1 (2017)
Review paper
Published online: 2017-03-01
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Partial agonism and full efficacy. Pharmacological profile and clinical application of aripiprazole

Magdalena Więdłocha, Agata Szulc
Psychiatria 2017;14(1):1-6.

open access

Vol 14, No 1 (2017)
Prace poglądowe - nadesłane
Published online: 2017-03-01

Abstract

Aripiprazole has among other antipsychotic agents a unique receptor profile, which results in its therapeutic effect and tolerability. In a situation of excess dopamine the compound acts similarly to other antipsychotics, whereas in dopamine deficit it exhibits agonistic properties. Numerous studies have documented that aripiprazole is efficacious for schizophrenia and bipolar disorder treatment. In a dose dependent manner, it may be used in the acute phase of illness or in maintenance therapy. The partial D2 receptor agonism prevents the occurrence of dopaminergic deficit resulting in less common parkinsonism, hyperprolactinemia and up-regulation of dopamine receptors. Aripiprazole has no clinically significant influence on weight gain, cardio-vascular disorders or metabolic parameters. This article presents the therapeutic applications of aripiprazole with emphasis on its administration during acute psychosis and mania, its dose-dependent effect and profile of tolerability.

Abstract

Aripiprazole has among other antipsychotic agents a unique receptor profile, which results in its therapeutic effect and tolerability. In a situation of excess dopamine the compound acts similarly to other antipsychotics, whereas in dopamine deficit it exhibits agonistic properties. Numerous studies have documented that aripiprazole is efficacious for schizophrenia and bipolar disorder treatment. In a dose dependent manner, it may be used in the acute phase of illness or in maintenance therapy. The partial D2 receptor agonism prevents the occurrence of dopaminergic deficit resulting in less common parkinsonism, hyperprolactinemia and up-regulation of dopamine receptors. Aripiprazole has no clinically significant influence on weight gain, cardio-vascular disorders or metabolic parameters. This article presents the therapeutic applications of aripiprazole with emphasis on its administration during acute psychosis and mania, its dose-dependent effect and profile of tolerability.

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Keywords

aripiprazole, schizophrenia, bipolar disorder

About this article
Title

Partial agonism and full efficacy. Pharmacological profile and clinical application of aripiprazole

Journal

Psychiatria (Psychiatry)

Issue

Vol 14, No 1 (2017)

Article type

Review paper

Pages

1-6

Published online

2017-03-01

Bibliographic record

Psychiatria 2017;14(1):1-6.

Keywords

aripiprazole
schizophrenia
bipolar disorder

Authors

Magdalena Więdłocha
Agata Szulc

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