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Published online: 2024-12-10

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Circulatory microRNAs in acute coronary syndrome: An update

Stefan Stojkovic1, Johann Wojta23

Abstract

Micro-ribonucleic acids (miRs) are small, non-coding RNAs, which play an important role in atherosclerotic plaque formation, development and stability. Plaque destabilization and rupture lead to acute coronary syndromes (ACS). Previous studies have implicated several different miRs in the pathogenesis of atherosclerosis. A number of circulating miRs emerged as promising diagnostic and prognostic biomarkers in ACS. Particularly cardiac- and muscle-enriched miRs including miR-1, miR-133a, miR-133b, miR-208a, and miR-499 were associated with myocardial damage and thus proposed as potential biomarkers of ACS. In this review we summarize the role of circulating miRs as biomarkers for diagnosis and prognosis in patients with ACS, as well as recent advances and remaining challenges of miRs assessment.

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