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Adverse effects of opioid analgesics from the central nervous system
Affiliations- Zakład Farmakologii Klinicznej Katedry Farmakologii UJ CM w Krakowie, Ul. Grzegórzecka 16, 31-531 Kraków, Poland
- Zakład Zaburzeń Afektywnych Katedry Psychiatrii UJ CM., Kopernika 21a, 31-501 Kraków, Poland
open access
Abstract
Opioid analgesic drugs are widely used in the treatment of moderate to severe pain as well as symptomatic
treatment of dyspnoea. However, the use of opioids may cause central adverse effects, such as delirium,
cognitive impairment, sedation, hallucinations, myocloni, seizures, hyperalgesia, sleep and mood disorders.
The ability to diagnose and properly manage the above adverse effects is important for the proper
treatment of patients receiving opioid analgesics.
Abstract
Opioid analgesic drugs are widely used in the treatment of moderate to severe pain as well as symptomatic
treatment of dyspnoea. However, the use of opioids may cause central adverse effects, such as delirium,
cognitive impairment, sedation, hallucinations, myocloni, seizures, hyperalgesia, sleep and mood disorders.
The ability to diagnose and properly manage the above adverse effects is important for the proper
treatment of patients receiving opioid analgesics.
Keywords
hyperalgesia, delirium, opioid analgesic drugs, adverse effects, neurotoxicity
About this articleTitle
Adverse effects of opioid analgesics from the central nervous system
Journal
Palliative Medicine in Practice
Issue
Article type
Review paper
Pages
241-247
Published online
2021-05-20
Page views
6716
Article views/downloads
1634
DOI
10.5603/PMPI.2021.0013
Bibliographic record
Palliat Med Pract 2021;15(3):241-247.
Keywords
hyperalgesia
delirium
opioid analgesic drugs
adverse effects
neurotoxicity
Authors
Krzysztof Wojtasik-Bakalarz
Jarosław Woroń
Marcin Siwek
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