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TP53 mutation in children with therapy-related myelodysplastic syndrome/acute myeloid leukemia after rhabdomyosarcoma treatment
, 1
Affiliations- Uniwersytet Medyczny w Poznaniu, Fredry 10, Poznan, Poland
open access
Abstract
After successful treatment of childhood malignancy, development of second malignancy (SM) is the most
devastating and potentially life-threatening sequelae of it. In the past 12 years there have been no cases
of therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) among 80 children
treated for soft tissue sarcomas (STS) in the Department of Paediatric Oncology, Haematology, and Bone
Marrow Transplantation. Given the rarity of recognition of t-MDS/AML in children after treatment of
cancers, it was decided to analyse in detail the therapy and cytogenetic and molecular results in two boys
aged 9 and 10 years old, diagnosed with t-MDS/AML secondary to rhabdomyosarcoma. In both of them
TP53 mutation was found.
Palliat Med Pract 2020; 14, 1: 58–62
Abstract
After successful treatment of childhood malignancy, development of second malignancy (SM) is the most
devastating and potentially life-threatening sequelae of it. In the past 12 years there have been no cases
of therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) among 80 children
treated for soft tissue sarcomas (STS) in the Department of Paediatric Oncology, Haematology, and Bone
Marrow Transplantation. Given the rarity of recognition of t-MDS/AML in children after treatment of
cancers, it was decided to analyse in detail the therapy and cytogenetic and molecular results in two boys
aged 9 and 10 years old, diagnosed with t-MDS/AML secondary to rhabdomyosarcoma. In both of them
TP53 mutation was found.
Palliat Med Pract 2020; 14, 1: 58–62
Keywords
acute myeloid leukaemia, children, myelodysplastic syndrome, rhabdomyosarcoma, TP53 mutation
About this articleTitle
TP53 mutation in children with therapy-related myelodysplastic syndrome/acute myeloid leukemia after rhabdomyosarcoma treatment
Journal
Palliative Medicine in Practice
Issue
Article type
Case report
Pages
58-62
Published online
2020-05-08
Page views
1091
Article views/downloads
677
DOI
Bibliographic record
Palliat Med Pract 2020;14(1):58-62.
Keywords
acute myeloid leukaemia
children
myelodysplastic syndrome
rhabdomyosarcoma
TP53 mutation
Authors
Ewelina Gowin
Danuta Januszkiewicz-Lewandowska
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