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Paraneoplastic hypertrophic pulmonary osteoarthropathy and pain management: a case report
Affiliations- Uniwerytet Medyczny, Al. Kściuszki 4, Łódź, Poland
- Hospital San Juan de Dios, Calle Beloso Alto 3, 31006 Pamplona, Spain
open access
Abstract
Hypertrophic osteoarthropathy (HOA) is a syndrome that consists of periostitis, digital clubbing, and painful
polyarthropathy. The management and prognosis of HOA is dependent on the underlying disease process.
Recognising and treating it accordingly will reduce the symptom burden of patients. We present a case
of a patient diagnosed with non-small cell lung cancer and HOA suffering from severe pain, and review
specific therapies for the management of HOA-related pain.
Abstract
Hypertrophic osteoarthropathy (HOA) is a syndrome that consists of periostitis, digital clubbing, and painful
polyarthropathy. The management and prognosis of HOA is dependent on the underlying disease process.
Recognising and treating it accordingly will reduce the symptom burden of patients. We present a case
of a patient diagnosed with non-small cell lung cancer and HOA suffering from severe pain, and review
specific therapies for the management of HOA-related pain.
Keywords
paraneoplastic hypertrophic osteoarthropathy, non-small cell lung cancer, digital clubbing, painful polyarthropathy
About this articleTitle
Paraneoplastic hypertrophic pulmonary osteoarthropathy and pain management: a case report
Journal
Palliative Medicine in Practice
Issue
Article type
Case report
Pages
248-251
Published online
2020-01-03
Page views
1211
Article views/downloads
895
DOI
Bibliographic record
Palliat Med Pract 2019;13(4):248-251.
Keywords
paraneoplastic hypertrophic osteoarthropathy
non-small cell lung cancer
digital clubbing
painful polyarthropathy
Authors
Aleksandra Masłowska
Marcin Rutkowski
Alba Gabriela Picco Brunetto
References (11)- Kilaru M, Vitale C, Montagnini M. Pain management in hypertrophic pulmonary osteoarthropathy: an illustrative case and review. Am J Hosp Palliat Care. 2012; 29(4): 302–307.
- Ribigan AC, Bajenaru OL, Antochi FA, et al. Nociceptive pain unmasking a serious pathology - paraneoplastic hypertrophic osteoarthropathy: A case report. Medicine (Baltimore). 2019; 98(23): e15900.
- Nguyen S, Hojjati M. Review of current therapies for secondary hypertrophic pulmonary osteoarthropathy. Clin Rheumatol. 2011; 30(1): 7–13.
- Pourmorteza M, Baumrucker SJ, Al-Sheyyab A, et al. Hypertrophic Pulmonary Osteoarthropathy: A Rare But Treatable Condition in Palliative Medicine. J Pain Symptom Manage. 2015; 50(2): 263–267.
- Ito T, Goto K, Yoh K, et al. Hypertrophic pulmonary osteoarthropathy as a paraneoplastic manifestation of lung cancer. J Thorac Oncol. 2010; 5(7): 976–980.
- Chakraborty RK, Sharma S. Secondary Hypertrophic Osteoarthropathy. In: StatPearls. Treasure Island, FL, 2019. https://www.ncbi.nlm.nih.gov/ books/NBK513342/ (April 2019).
- Sonthalia N, Mukherjee K, Saha A, et al. Treatment of hypertrophic osteoarthropathy in the case of pulmonary metastasis secondary-to-nasopharyngeal carcinoma with zoledronic acid: an enlightening experience. BMJ Case Rep. 2012; 2012.
- Jayakar BA, Abelson AG, Yao Q. Treatment of hypertrophic osteoarthropathy with zoledronic acid: case report and review of the literature. Semin Arthritis Rheum. 2011; 41(2): 291–296.
- Tachibana I, Gehi D, Rubin CD. Treatment of Hypertrophic Osteoarthropathy With Underlying Pulmonary Adenocarcinoma Using Zoledronic Acid. J Clin Rheumatol. 2015; 21(6): 333–334.
- Angel-Moreno Maroto A, Martínez-Quintana E, Suárez-Castellano L, et al. Painful hypertrophic osteoarthropathy successfully treated with octreotide. The pathogenetic role of vascular endothelial growth factor (VEGF). Rheumatology (Oxford). 2005; 44(10): 1326–1327.
- Openshaw MR, Rowan CS, Grumett S. Atypical hypertrophic osteoartropathy as a presenting complaint in a non-smoker. J Med Cases. 2013; 4: 204–207.
