open access
Vol 13, No 2 (2019)
Review paper
Published online: 2019-06-05
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Immunology for palliative medicine specialists. The role of Toll-like receptors in inducing disease symptoms
12
Affiliations- International Association for Study on Pain, United States
- European Association for Palliative Care, Italy
open access
Vol 13, No 2 (2019)
Review paper
Published online: 2019-06-05
Abstract
Organizm ludzki ochraniany jest przed czynnikami szkodliwymi pochodzącymi ze świata zewnętrznego i wewnętrznego poprzez system odporności wrodzonej i nabytej, które współpracują ze sobą zarówno u osób zdrowych, jak i u chorych. Receptory Toll-like zlokalizowane są na powierzchni komórek mikrogleju i biorą udział w rozwoju zapalenia neurogennego, które z kolei prowadzi do wystąpienia wielu chorób i objawów, takich jak: depresja, zmęczenie, ból przewlekły i neuropatyczny, kaszel, zaparcie stolca i świąd. Aktywację receptorów Toll-like hamują między innymi leki przeciwdepresyjne. Prawdopodobnie w niedalekiej przyszłości poznane zostaną nowsze leki, skuteczniej hamujące rozwój zapalenia neurogennego, co pozwoli skuteczniej leczyć objawy oporne na standardową farmakoterapię.
Abstract
Organizm ludzki ochraniany jest przed czynnikami szkodliwymi pochodzącymi ze świata zewnętrznego i wewnętrznego poprzez system odporności wrodzonej i nabytej, które współpracują ze sobą zarówno u osób zdrowych, jak i u chorych. Receptory Toll-like zlokalizowane są na powierzchni komórek mikrogleju i biorą udział w rozwoju zapalenia neurogennego, które z kolei prowadzi do wystąpienia wielu chorób i objawów, takich jak: depresja, zmęczenie, ból przewlekły i neuropatyczny, kaszel, zaparcie stolca i świąd. Aktywację receptorów Toll-like hamują między innymi leki przeciwdepresyjne. Prawdopodobnie w niedalekiej przyszłości poznane zostaną nowsze leki, skuteczniej hamujące rozwój zapalenia neurogennego, co pozwoli skuteczniej leczyć objawy oporne na standardową farmakoterapię.
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Keywords
innate immunity, acquired immunity, microglia, Toll-like receptors, Pro-nociceptive cytokines, neurogenic inflammation
About this articleTitle
Immunology for palliative medicine specialists. The role of Toll-like receptors in inducing disease symptoms
Journal
Palliative Medicine in Practice
Issue
Article type
Review paper
Pages
57-64
Published online
2019-06-05
Page views
851
Article views/downloads
679
DOI
Bibliographic record
Palliat Med Pract 2019;13(2):57-64.
Keywords
innate immunity
acquired immunity
microglia
Toll-like receptors
Pro-nociceptive cytokines
neurogenic inflammation
Authors
Zbigniew Żylicz
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