Vol 15, No 3 (2021)
Review paper
Published online: 2021-05-20

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Adverse effects of opioid analgesics from the central nervous system

Krzysztof Wojtasik-Bakalarz1, Jarosław Woroń1, Marcin Siwek2
DOI: 10.5603/PMPI.2021.0013
Palliat Med Pract 2021;15(3):241-247.


Opioid analgesic drugs are widely used in the treatment of moderate to severe pain as well as symptomatic
treatment of dyspnoea. However, the use of opioids may cause central adverse effects, such as delirium,
cognitive impairment, sedation, hallucinations, myocloni, seizures, hyperalgesia, sleep and mood disorders.
The ability to diagnose and properly manage the above adverse effects is important for the proper
treatment of patients receiving opioid analgesics.

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