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Drug selection in the treatment of breakthrough pain: how the pharmacokinetic profile of drugsis to be translated into clinical practice
Affiliations- zakład farmakologii klinicznej katedry farmakologii wydział lekarski uj cm kraków, śniadeckich 10, 31-531 kraków, Poland
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Abstract
Breakthrough pain in cancer patients (BTP), also referred to as episodic or incident pain, occurs in a signif-icant proportion of patients with baseline pain (40–60%). It is characterized by rapid intensifying (within tens of seconds or a few minutes) and a strong intensity in the numerical rating scale always above 5 and a limited duration, usually up to about 60 minutes. The choice of the drug for the management of BTP in clinical practice should be based on a profound knowledge of pathophysiology of BTP and pharmacokinetic parameters of the drugs used.
Abstract
Breakthrough pain in cancer patients (BTP), also referred to as episodic or incident pain, occurs in a signif-icant proportion of patients with baseline pain (40–60%). It is characterized by rapid intensifying (within tens of seconds or a few minutes) and a strong intensity in the numerical rating scale always above 5 and a limited duration, usually up to about 60 minutes. The choice of the drug for the management of BTP in clinical practice should be based on a profound knowledge of pathophysiology of BTP and pharmacokinetic parameters of the drugs used.
About this articleTitle
Drug selection in the treatment of breakthrough pain: how the pharmacokinetic profile of drugsis to be translated into clinical practice
Journal
Palliative Medicine in Practice
Issue
Article type
Review paper
Pages
211-215
Published online
2019-09-27
Page views
1009
Article views/downloads
674
DOI
Bibliographic record
Palliat Med Pract 2019;13(4):211-215.
Authors
Jarosław Woroń
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