open access

Vol 11, No 2 (2017)
Review paper
Published online: 2017-10-12
Get Citation

Mechanisms of opioid analgesics addiction

Ryszard Przewłocki
Medycyna Paliatywna w Praktyce 2017;11(2):55-60.

open access

Vol 11, No 2 (2017)
Review articles
Published online: 2017-10-12

Abstract

Opioid addiction (opioid use disorder) is a chronic, relapsing disease of brain. Opioids induced persisting changes at the cellular and molecular levels resulted in dysregulation and remodeling of the reward system. These changes depend on genetic and environmental factors. Therapy of opioid addiction is limited and require both pharmacological therapy and psychotherapy. Understanding the neurobiological mechanisms of opioid addiction is essential for a better treatment of this disease.

Abstract

Opioid addiction (opioid use disorder) is a chronic, relapsing disease of brain. Opioids induced persisting changes at the cellular and molecular levels resulted in dysregulation and remodeling of the reward system. These changes depend on genetic and environmental factors. Therapy of opioid addiction is limited and require both pharmacological therapy and psychotherapy. Understanding the neurobiological mechanisms of opioid addiction is essential for a better treatment of this disease.

Get Citation

Keywords

addiction, opioids, reward system

About this article
Title

Mechanisms of opioid analgesics addiction

Journal

Palliative Medicine in Practice

Issue

Vol 11, No 2 (2017)

Article type

Review paper

Pages

55-60

Published online

2017-10-12

Bibliographic record

Medycyna Paliatywna w Praktyce 2017;11(2):55-60.

Keywords

addiction
opioids
reward system

Authors

Ryszard Przewłocki

References (11)
  1. Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology. 2001; 24(2): 97–129.
  2. Lüscher C, Malenka RC. Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron. 2011; 69(4): 650–663.
  3. Volkow ND, Koob GF, McLellan AT. Neurobiologic Advances from the Brain Disease Model of Addiction. N Engl J Med. 2016; 374(4): 363–371.
  4. Kieffer BL, Gavériaux-Ruff C. Exploring the opioid system by gene knockout. Prog Neurobiol. 2002; 66(5): 285–306.
  5. Przewlocki R. Opioid peptides. in D.W. Pfaff, N.D. Volkow (eds.), Neuroscience in the 21st Century. Springer Science+Business Media New York, 2016.
  6. Kreek MJ, Levran O, Reed B, et al. Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. J Clin Invest. 2012; 122(10): 3387–3393.
  7. Pasternak GW. Opioids and their receptors: Are we there yet? Neuropharmacology. 2014; 76 Pt B: 198–203.
  8. Kenny PJ. Epigenetics, microRNA, and addiction. Dialogues Clin Neurosci. 2014; 16(3): 335–344.
  9. DeWire SM, Yamashita DS, Rominger DH, et al. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther. 2013; 344(3): 708–717.
  10. Spahn V, Del Vecchio G, Labuz D, et al. A nontoxic pain killer designed by modeling of pathological receptor conformations. Science. 2017; 355(6328): 966–969.
  11. Manglik A, Lin H, Aryal DK, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016; 537(7619): 185–190.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Medycyna Paliatywna w Praktyce dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl