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Mechanisms of opioid analgesics addiction
Affiliations- Via Medica, Swietokrzyska Str. 73, 80-180 Gdansk
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Abstract
Opioid addiction (opioid use disorder) is a chronic, relapsing disease of brain. Opioids induced persisting changes at the cellular and molecular levels resulted in dysregulation and remodeling of the reward system. These changes depend on genetic and environmental factors. Therapy of opioid addiction is limited and require both pharmacological therapy and psychotherapy. Understanding the neurobiological mechanisms of opioid addiction is essential for a better treatment of this disease.
Abstract
Opioid addiction (opioid use disorder) is a chronic, relapsing disease of brain. Opioids induced persisting changes at the cellular and molecular levels resulted in dysregulation and remodeling of the reward system. These changes depend on genetic and environmental factors. Therapy of opioid addiction is limited and require both pharmacological therapy and psychotherapy. Understanding the neurobiological mechanisms of opioid addiction is essential for a better treatment of this disease.
Keywords
addiction, opioids, reward system
About this articleTitle
Mechanisms of opioid analgesics addiction
Journal
Palliative Medicine in Practice
Issue
Article type
Review paper
Pages
55-60
Published online
2017-10-12
Page views
805
Article views/downloads
11044
Bibliographic record
Medycyna Paliatywna w Praktyce 2017;11(2):55-60.
Keywords
addiction
opioids
reward system
Authors
Ryszard Przewłocki
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