Vol 11, No 2 (2017)
Review paper
Published online: 2017-10-12
Basic mechanisms of analgesic effects of opioids
Medycyna Paliatywna w Praktyce 2017;11(2):48-54.
Abstract
In the 70s of the last century, intensive studies and discoveries have begun concerning the structure and function of endogenous opioids, which are the main endogenous antinociceptive system. This period has resulted in many discoveries that are important for understanding the mechanism of opioid action. Knowledge about the structure and function of endogenous opioid systems, the distribution and function of the three types of opioid receptors, and the changes in these systems in different types of pain have been systematized. These discoveries are the basis for the development of effective search for new drugs with strong analgesic effects and the limited occurrence of side effects and for development a new pain therapy.
Keywords: endogenous opioid systemsopioid receptorsopioid analgesia
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