open access

Vol 11, No 2 (2017)
Review paper
Published online: 2017-10-12
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Basic mechanisms of analgesic effects of opioids

Barbara Przewłocka
Medycyna Paliatywna w Praktyce 2017;11(2):48-54.

open access

Vol 11, No 2 (2017)
Review articles
Published online: 2017-10-12

Abstract

In the 70s of the last century, intensive studies and discoveries have begun concerning the structure and function of endogenous opioids, which are the main endogenous antinociceptive system. This period has resulted in many discoveries that are important for understanding the mechanism of opioid action. Knowl­edge about the structure and function of endogenous opioid systems, the distribution and function of the three types of opioid receptors, and the changes in these systems in different types of pain have been systematized. These discoveries are the basis for the development of effective search for new drugs with strong analgesic effects and the limited occurrence of side effects and for development a new pain therapy.

Abstract

In the 70s of the last century, intensive studies and discoveries have begun concerning the structure and function of endogenous opioids, which are the main endogenous antinociceptive system. This period has resulted in many discoveries that are important for understanding the mechanism of opioid action. Knowl­edge about the structure and function of endogenous opioid systems, the distribution and function of the three types of opioid receptors, and the changes in these systems in different types of pain have been systematized. These discoveries are the basis for the development of effective search for new drugs with strong analgesic effects and the limited occurrence of side effects and for development a new pain therapy.

Get Citation

Keywords

endogenous opioid systems, opioid receptors, opioid analgesia

About this article
Title

Basic mechanisms of analgesic effects of opioids

Journal

Palliative Medicine in Practice

Issue

Vol 11, No 2 (2017)

Article type

Review paper

Pages

48-54

Published online

2017-10-12

Bibliographic record

Medycyna Paliatywna w Praktyce 2017;11(2):48-54.

Keywords

endogenous opioid systems
opioid receptors
opioid analgesia

Authors

Barbara Przewłocka

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