open access

Vol 10, No 4 (2016)
Review paper
Published online: 2017-05-19
Get Citation

Pharmacological means to improve patients’ mood. Are they effective and safe?

Zbigniew Ben Zylicz
Medycyna Paliatywna w Praktyce 2016;10(4):155-159.

open access

Vol 10, No 4 (2016)
Review articles
Published online: 2017-05-19

Abstract

Low mood and depression can be treated with many non-pharmacological means. However, in terminally ill these means are sometimes insufficient and the doctors need to prescribe drugs. In this article I shall discuss simple and proven drugs that improve patients mood and, some of them do have proven antidepressant activity. I shall discuss methylphenidate, ketamine, cannabinoids and buprenorphine in more detail. Cautious use of these drugs in different clinical situations may improve nearly instantly quality of life and quality of dying. However, unskilled use of some of them may result in earlier death, neurosis, epilepsy and even psychosis.

Abstract

Low mood and depression can be treated with many non-pharmacological means. However, in terminally ill these means are sometimes insufficient and the doctors need to prescribe drugs. In this article I shall discuss simple and proven drugs that improve patients mood and, some of them do have proven antidepressant activity. I shall discuss methylphenidate, ketamine, cannabinoids and buprenorphine in more detail. Cautious use of these drugs in different clinical situations may improve nearly instantly quality of life and quality of dying. However, unskilled use of some of them may result in earlier death, neurosis, epilepsy and even psychosis.

Get Citation

Keywords

mood enhancement, low mood, depression antidepressant activity, methylphenidate, ketamine, cannabinoids, buprenorphine

About this article
Title

Pharmacological means to improve patients’ mood. Are they effective and safe?

Journal

Palliative Medicine in Practice

Issue

Vol 10, No 4 (2016)

Article type

Review paper

Pages

155-159

Published online

2017-05-19

Bibliographic record

Medycyna Paliatywna w Praktyce 2016;10(4):155-159.

Keywords

mood enhancement
low mood
depression antidepressant activity
methylphenidate
ketamine
cannabinoids
buprenorphine

Authors

Zbigniew Ben Zylicz

References (34)
  1. Lloyd-Williams M, Dennis M, Taylor FA. prospective study to compare three depression screening tools in patients who are terminally ill. Gen Hosp Psychiatry. 2004; 26: 384–389.
  2. van der Lee ML, van der Bom JG, Swarte NB, et al. Euthanasia and depression: a prospective cohort study among terminally ill cancer patients. J Clin Oncol. 2005; 23(27): 6607–6612.
  3. Asghar-Ali AA, Wagle KC, Braun UK. Depression in terminally ill patients: dilemmas in diagnosis and treatment. Journal of pain and symptom management. 2013; 45: 926–933.
  4. Breitbart W, Rosenfeld B, Pessin H, et al. Depression, hopelessness, and desire for hastened death in terminally ill patients with cancer. JAMA : the journal of the American Medical Association. 2000; 284: 2907–2911.
  5. Mendoza ME, Capafons A, Gralow JR, et al. Randomized controlled trial of the Valencia model of waking hypnosis plus CBT for pain, fatigue, and sleep management in patients with cancer and cancer survivors. : Psychooncology.
  6. Johnson JA, Rash JA, Campbell TS, et al. et al.. A systematic review and meta-analysis of randomized controlled trials of cognitive behavior therapy for insomnia (CBT-I) in cancer survivors. Sleep Med Rev. 2016; 27: 20–28.
  7. Yennurajalingam S, Palmer JL, Chacko R, et al. Factors associated with response to methylphenidate in advanced cancer patients. The oncologist. 2011; 16: 246–253.
  8. Homsi J, Nelson KA, Sarhill N, et al. et al.. A phase II study of methylphenidate for depression in advanced cancer. The American journal of hospice & palliative care. 2001; 18: 403–407.
  9. Koutsky CD, Westendorp F, Bransford P. High dosage methylphenidate for depression. Dis Nerv Syst. 1960; 21: 275–277.
  10. Katon W, Raskind M. Treatment of depression in the medically ill elderly with methylphenidate. Am J Psychiatry. 1980; 137(8): 963–965.
  11. Moore DP. Methylphenidate in depression and states of apathy. South Med J. 1981; 74: 347–348.
  12. Brown P, Brawley P. Dexamethasone suppression test and mood response to methylphenidate in primary depression. Am J Psychiatry. 1983; 140(8): 990–993.
  13. Sabelli HC, Fawcett J, Javaid JI, et al. The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression. Am J Psychiatry. 1983; 140(2): 212–214.
  14. Sullivan D, Mongoue-Tchokote S, Mori M, et al. Randomized, double-blind, placebo-controlled study of methylphenidate for the treatment of depression in SSRI-treated cancer patients receiving palliative care. Psycho-Oncology. 2016.
  15. Mattes JA. Methylphenidate in mild depression: a double-blind controlled trial. J Clin Psychiatry. 1985; 46(12): 525–527.
  16. Lavretsky H, Reinlieb M, St Cyr N, et al. Citalopram, methylphenidate, or their combination in geriatric depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2015; 172(6): 561–569.
  17. Park YM, Jung YK. Manic switch and serotonin syndrome induced by augmentation of paroxetine with methylphenidate in a patient with major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34(4): 719–720.
  18. Kotlińska-Lemieszek A, Luczak J. Subanesthetic ketamine: an essential adjuvant for intractable cancer pain. J Pain Symptom Manage. 2004; 28(2): 100–102.
  19. Bell RF, Eccleston C, Kalso EA, et al. Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst Rev. 2003; 26(1): CD003351–875.
  20. Blonk MI, Koder BG, van den Bemt PM, et al. Use of oral ketamine in chronic pain management: a review. Eur J Pain. 2010; 14(5): 466–472.
  21. Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000; 47(4): 351–354.
  22. Liebrenz M, Borgeat A, Leisinger R, et al. Intravenous ketamine therapy in a patient with a treatment-resistant major depression. Swiss Med Wkly. 2007; 137(15-16): 234–236.
  23. Liebrenz M, Stohler R, Borgeat A. Repeated intravenous ketamine therapy in a patient with treatment-resistant major depression. World J Biol Psychiatry. 2009; 10(4 Pt 2): 640–643.
  24. Iadarola ND, Niciu MJ, Richards EM, et al. Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther Adv Chronic Dis. 2015; 6(3): 97–114.
  25. Zarate CA, Niciu MJ. Ketamine for depression: evidence, challenges and promise. World Psychiatry. 2015; 14(3): 348–350.
  26. Xu Y, Hackett M, Carter G, et al. Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis. Int J Neuropsychopharmacol. 2016; 19(4).
  27. Alberich S, Martínez-Cengotitabengoa M, López P, et al. Efficacy and safety of ketamine in bipolar depression: A systematic review. Rev Psiquiatr Salud Ment. 2016 [Epub ahead of print].
  28. Parsaik AK, Singh B, Khosh-Chashm D, et al. Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis. J Psychiatr Pract. 2015; 21(6): 427–435.
  29. Andrade C. Cannabis and neuropsychiatry, 1: benefits and risks. J Clin Psychiatry. 2016; 77(5): e551–e554.
  30. van den Elsen GAH, Ahmed AIA, Lammers M, et al. Efficacy and safety of medical cannabinoids in older subjects: a systematic review. Ageing Res Rev. 2014; 14: 56–64.
  31. Emrich HM, Vogt P, Herz A, Kissling W. Antidepressant effects of buprenorphine.Emrich HM, Vogt P, Herz A, Kissling W. ed. Lancet 1982: 709.
  32. Li W, Sun H, Chen H, et al. Major Depressive Disorder and Kappa Opioid Receptor Antagonists. Transl Perioper Pain Med. 2016; 1(2): 4–16.
  33. Karp JF, Butters MA, Begley AE, et al. Safety, tolerability, and clinical effect of low-dose buprenorphine for treatment-resistant depression in midlife and older adults. J Clin Psychiatry. 2014; 75(8): e785–e793.
  34. Peciña M, Bohnert ASB, Sikora M, et al. Association Between Placebo-Activated Neural Systems and Antidepressant Responses: Neurochemistry of Placebo Effects in Major Depression. JAMA Psychiatry. 2015; 72(11): 1087–1094.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Czasopismo Medycyna Paliatywna w Praktyce dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl