Vol 10, No 2 (2016)
Review paper
Published online: 2016-11-29
What do we know about influence of opioids on immune system?
Medycyna Paliatywna w Praktyce 2016;10(2):59-65.
Abstract
Opioid effects on the immune system is a complex phenomenon which depends on the following variables: type of the opioid drug, the nature of the response (humoral or cellular), and the type of cells involved in its course. Macrophages appear to play an important role in modulating the signal of the opioid.
This is confirmed by the results of research conducted by a group of researchers from Krakow, which evaluated the effect of treatment with different opioids on the parameters of humoral and cellular immunity. While studies with morphine, fentanyl, and methadone has been completed, research on oxycodone and buprenorphine are still conducted. The work will be covered by the so far obtained results of experimental usage of these opioids.
Keywords: opioidsimmune systemhumoral and cellular immunity
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