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Published online: 2024-05-17

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Facebook counselling in the field of complementary and alternative medicine (CAM) among Polish breast cancer patients: a narrative review

Aneta Brygida Jędrzejewska1, Barbara Janina Ślusarska1, Grzegorz Józef Nowicki1
DOI: 10.5603/pmp.100311

Abstract

Introduction: Breast cancer (BC) patients often use complementary and integrative therapies as supportive care as suggested by on-line sources during cancer treatment and when coping with the side effects of treatment. However, the evidence for the effectiveness of such therapies is limited. The aim of this review was to critically analyse Facebook's advice to women with BC regarding the use of complementary and alternative medicine (CAM) and assess their safety and effectiveness.

Methods: Narrative review.

Results: The search yielded 1,300 pieces of advice provided by the community of Facebook groups. These were analysed, and their safety and effectiveness were assessed. Many different CAM therapies were identified, which were grouped into five categories.

Conclusions: Currently, searching for information on CAM on Polish-language Facebook groups by breast cancer patients poses a risk of obtaining advice of unproven effectiveness. Patients are exposed to suggestions that they should take products that may interact with conventional treatment or that they may be persuaded to give up conventional treatment. Cancer care providers should consider the complexity and implications of the unmet need for information and support for breast cancer patients that result in seeking CAM advice on Facebook groups. Measures should be taken to ensure that breast cancer patients can find reliable evidence on CAM online in social media.

Keywords: complementary and alternative medicinebreast canceronline health information-seekingsocial mediamisinformation

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References

  1. Complementary, alternative, or integrative health: What’s in a name?; NCCIH. https://www.nccih.nih.gov/health/complementary-alternative-or-integrative-health-whats-in-a-name (6.12.2021).
  2. Witt CM, Balneaves LG, Cardoso MJ, et al. A comprehensive definition for integrative oncology. J Natl Cancer Inst Monogr. 2017; 2017(52): 3–8.
    CrossRefPubMed
  3. Jędrzejewska A, Ślusarska BJ, Szadowska-Szlachetka Z, et al. Use of complementary and alternative medicine in patients with cancer and their relationship with health behaviours — cross–sectional study. Ann Agric Environ Med. 2021; 28(3): 475–482.
    CrossRefPubMed
  4. Theuser AK, Hack CC, Fasching PA, et al. Patterns and trends of herbal medicine use among patients with gynecologic cancer. Geburtshilfe Frauenheilkd. 2021; 81(6): 699–707.
    CrossRefPubMed
  5. Wolf CP, Rachow T, Ernst T, et al. Interactions in cancer treatment considering cancer therapy, concomitant medications, food, herbal medicine and other supplements. J Cancer Res Clin Oncol. 2022; 148(2): 461–473.
    CrossRefPubMed
  6. Kufel-Grabowska J, Bartoszkiewicz M. Complementary and alternative therapies in oncology. Nowotwory J Oncol. 2022; 72(2): 135–136.
    CrossRef
  7. Behzadmehr R, Dastyar N, Moghadam MP, et al. Effect of complementary and alternative medicine interventions on cancer related pain among breast cancer patients: A systematic review. Complement Ther Med. 2020; 49: 102318.
    CrossRefPubMed
  8. Wanchai A, Armer JM, Stewart BR. Complementary and alternative medicine use among women with breast cancer: a systematic review. Clin J Oncol Nurs. 2010; 14(4): E45–E55.
    CrossRefPubMed
  9. Greenlee H, Balneaves LG, Carlson LE, et al. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr. 2014; 2014(50): 346–358.
    CrossRefPubMed
  10. Ambrosone CB, Zirpoli GR, Hutson AD, et al. Dietary supplement use during chemotherapy and survival outcomes of patients with breast cancer enrolled in a cooperative group clinical trial (SWOG S0221). J Clin Oncol. 2020; 38(8): 804–814.
    CrossRefPubMed
  11. Ben-Arye E, Samuels N, Goldstein LH, et al. Potential risks associated with traditional herbal medicine use in cancer care: a study of middle eastern oncology health care professionals. Cancer. 2016; 122(4): 598–610.
    CrossRefPubMed
  12. Keene MR, Heslop IM, Sabesan SS, et al. Complementary and alternative medicine use in cancer: a systematic review. Complement Ther Clin Pract. 2019; 35: 33–47.
    CrossRefPubMed
  13. Kanimozhi T, Hindu K, Maheshvari Y, et al. Herbal supplement usage among cancer patients: a questionnaire-based survey. J Cancer Res Ther. 2021; 17(1): 136–141.
    CrossRefPubMed
  14. Mohamed MEF, Frye RF. Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies. Planta Med. 2011; 77(4): 311–321.
    CrossRefPubMed
  15. Firkins R, Eisfeld H, Keinki C, et al. The use of complementary and alternative medicine by patients in routine care and the risk of interactions. J Cancer Res Clin Oncol. 2018; 144(3): 551–557.
    CrossRefPubMed
  16. Moraliyage H, De Silva D, Ranasinghe W, et al. Cancer in lockdown: impact of the COVID-19 pandemic on patients with cancer. Oncologist. 2021; 26(2): e342–e344.
    CrossRefPubMed
  17. Moorhead SA, Hazlett DE, Harrison L, et al. A new dimension of health care: systematic review of the uses, benefits, and limitations of social media for health communication. J Med Internet Res. 2013; 15(4): e85.
    CrossRefPubMed
  18. De Angelis G, Wells GA, Davies B, et al. The use of social media among health professionals to facilitate chronic disease self-management with their patients: a systematic review. Digit Health. 2018; 4: 2055207618771416.
    CrossRefPubMed
  19. Antheunis ML, Tates K, Nieboer TE. Patients' and health professionals' use of social media in health care: motives, barriers and expectations. Patient Educ Couns. 2013; 92(3): 426–431.
    CrossRefPubMed
  20. Patel R, Chang T, Greysen SR, et al. Social media use in chronic disease: a systematic review and novel taxonomy. Am J Med. 2015; 128(12): 1335–1350.
    CrossRefPubMed
  21. Bender JL, Jimenez-Marroquin MC, Jadad AR. Seeking support on facebook: a content analysis of breast cancer groups. J Med Internet Res. 2011; 13(1): e16.
    CrossRefPubMed
  22. NatMed Pro. https://naturalmedicines.therapeuticresearch.com/ (2.01.2024).
  23. Thompson LU, Chen JM, Li T, et al. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res. 2005; 11(10): 3828–3835.
    CrossRefPubMed
  24. Harris HR, Orsini N, Wolk A. Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cancer. 2014; 50(7): 1223–1231.
    CrossRefPubMed
  25. Khazaei S, Nilsson L, Adrian G, et al. Impact of combining vitamin C with radiation therapy in human breast cancer: does it matter? Oncotarget. 2022; 13(1): 439–453.
    CrossRefPubMed
  26. Wang Z, Wang X, Wang Z, et al. Potential herb-drug interaction risk of thymoquinone and phenytoin. Chem Biol Interact. 2022; 353: 109801.
    CrossRefPubMed
  27. Fararh KM, Atoji Y, Shimizu Y, et al. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet Sci. 2004; 77(2): 123–129.
    CrossRefPubMed
  28. Massadeh AM, Al-Safi SA, Momani IF, et al. Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice. Biol Trace Elem Res. 2007; 115(2): 157–167.
    CrossRefPubMed
  29. Islam SkN, Begum P, Ahsan T, et al. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother Res. 2004; 18(5): 395–398.
    CrossRefPubMed
  30. Boskabady MH, Vahedi N, Amery S, et al. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J Ethnopharmacol. 2011; 137(2): 1028–1034.
    CrossRefPubMed
  31. Nasrin S, Watson CJW, Perez-Paramo YX, et al. Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions. Drug Metab Dispos. 2021; 49(12): 1070–1080.
    CrossRefPubMed
  32. Highlights of prescribing information. www.fda.gov/medwatch (21.12.2023).
  33. Parihar V, Rogers A, Blain AM, et al. Reduction in tamoxifen metabolites endoxifen and n-desmethyltamoxifen with chronic administration of low dose cannabidiol: a CYP3A4 and CYP2D6 drug interaction. J Pharm Pract. 2022; 35(2): 322–326.
    CrossRefPubMed
  34. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci. 2005; 77(19): 2438–2456.
    CrossRefPubMed
  35. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol. 2001; 53(10): 1323–1329.
    CrossRefPubMed
  36. Zou L, Harkey MR, Henderson GL. Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci. 2002; 71(13): 1579–1589.
    CrossRefPubMed
  37. Liu Y, Cui T, Peng Y, et al. Mechanism-based inactivation of cytochrome P450 2D6 by chelidonine. J Biochem Mol Toxicol. 2019; 33(2): e22251.
    CrossRefPubMed
  38. Teschke R, Glass X, Schulze J. Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports. Regul Toxicol Pharmacol. 2011; 61(3): 282–291.
    CrossRefPubMed
  39. Stickel F, Pöschl G, Seitz HK, et al. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand J Gastroenterol. 2003; 38(5): 565–568.
    CrossRefPubMed
  40. Moro PA, Cassetti F, Giugliano G, et al. Hepatitis from Greater celandine (Chelidonium majus L.): review of literature and report of a new case. J Ethnopharmacol. 2009; 124(2): 328–332.
    CrossRefPubMed
  41. Nowicky JW, Staniszewski A, Zbroja–Sontag W. et al. Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (“Ukrain”) as an immunostimulant in patients with various carcinomas. Drugs Exp Clin Res. 1991 Jan 1;17(2):139–143. https://europepmc.org/article/med/1713821 (21.12.2023).
  42. Damkier P, Lassen D, Christensen MM, et al. Interaction between warfarin and cannabis. Basic Clin Pharmacol Toxicol. 2019; 124(1): 28–31.
    CrossRefPubMed
  43. Chayasirisobhon S. Mechanisms of action and pharmacokinetics of cannabis. Perm J. 2020; 25: 1–3.
    CrossRefPubMed
  44. Zhu HJ, Wang JS, Markowitz JS, et al. Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana. J Pharmacol Exp Ther. 2006; 317(2): 850–857.
    CrossRefPubMed
  45. Tournier N, Chevillard L, Megarbane B, et al. Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010; 13(7): 905–915.
    CrossRefPubMed
  46. Peretz A, Nève J, Desmedt J, et al. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am J Clin Nutr. 1991; 53(5): 1323–1328.
    CrossRefPubMed
  47. Hou XL, Takahashi K, Kinoshita N, et al. Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. Int J Pharm. 2007; 337(1-2): 169–177.
    CrossRefPubMed
  48. Valentine SP, Le Nedelec MJ, Menzies AR, et al. Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse. Life Sci. 2006; 78(20): 2391–2398.
    CrossRefPubMed
  49. Yue GGL, Cheng SW, Yu H, et al. The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells. J Med Food. 2012; 15(3): 242–252.
    CrossRefPubMed
  50. Zhang W, Tan TM, Lim LY. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats. Drug Metab Dispos. 2007; 35(1): 110–115.
    CrossRefPubMed
  51. Mitchell TM. Correspondence re: Somasundaram et al., Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res., 62: 3868-3875, 2002. Cancer Res. 2003; 63(16): 5165–5166; author reply 5166–5167.
    PubMed
  52. Hussaarts KG, Hurkmans DP, Oomen-de Hoop E, et al. Impact of curcumin (with or without piperine) on the pharmacokinetics of tamoxifen. Cancers (Basel). 2019; 11(3).
    CrossRefPubMed
  53. Arzallus T, Izagirre A, Castiella A, et al. Drug induced autoimmune hepatitis after turmeric intake. Gastroenterol Hepatol. 2023; 46(10): 805–806.
    CrossRefPubMed
  54. Halegoua-DeMarzio D, Navarro V, Ahmad J, et al. Liver injury associated with turmeric-a growing problem: ten cases from the drug-induced liver injury network [DILIN]. Am J Med. 2023; 136(2): 200–206.
    CrossRefPubMed
  55. Yasueda A, Urushima H, Ito T. Efficacy and interaction of antioxidant supplements as adjuvant therapy in cancer treatment: a systematic review. Integr Cancer Ther. 2016; 15(1): 17–39.
    CrossRefPubMed
  56. Robien K, Oppeneer SJ, Kelly JA, et al. Drug-vitamin D interactions: a systematic review of the literature. Nutr Clin Pract. 2013; 28(2): 194–208.
    CrossRefPubMed
  57. Johnson SB, Park HS, Gross CP, et al. Use of alternative medicine for cancer and its impact on survival. J Natl Cancer Inst. 2018; 110(1): 121–124.
    CrossRefPubMed
  58. Johnson SB, Park HS, Gross CP, et al. Complementary medicine, refusal of conventional cancer therapy, and survival among patients with curable cancers. JAMA Oncol. 2018; 4(10): 1375–1381.
    CrossRefPubMed
  59. Jędrzejewska AB, Ślusarska BJ, Jurek K, et al. Translation and cross-cultural adaptation of the international questionnaire to measure the use of complementary and alternative medicine (I-CAM-Q) for the Polish and cross-sectional study. Int J Environ Res Public Health. 2022; 20(1): 124.
    CrossRefPubMed
  60. Kristoffersen AE, Quandt SA, Stub T. Use of complementary and alternative medicine in Norway: a cross-sectional survey with a modified Norwegian version of the international questionnaire to measure use of complementary and alternative medicine (I-CAM-QN). BMC Complement Med Ther. 2021; 21(1): 93.
    CrossRefPubMed
  61. Joseph K, Vrouwe S, Kamruzzaman A, et al. Outcome analysis of breast cancer patients who declined evidence-based treatment. World J Surg Oncol. 2012; 10: 118.
    CrossRefPubMed
  62. Dibble SL, Chapman J, Mack KA, et al. Acupressure for nausea: results of a pilot study. Oncol Nurs Forum. 2000; 27(1): 41–47.
    PubMed
  63. Molassiotis A, Helin AM, Dabbour R, et al. The effects of P6 acupressure in the prophylaxis of chemotherapy-related nausea and vomiting in breast cancer patients. Complement Ther Med. 2007; 15(1): 3–12.
    CrossRefPubMed
  64. Crane-Okada R, Kiger H, Sugerman F, et al. Mindful movement program for older breast cancer survivors: a pilot study. Cancer Nurs. 2012; 35(4): E1–13.
    CrossRefPubMed
  65. Kim YH, Kim HJ, Ahn SDo, et al. Effects of meditation on anxiety, depression, fatigue, and quality of life of women undergoing radiation therapy for breast cancer. Complement Ther Med. 2013; 21(4): 379–387.
    CrossRefPubMed
  66. Gan TJ, Jiao KR, Zenn M, et al. A randomized controlled comparison of electro-acupoint stimulation or ondansetron versus placebo for the prevention of postoperative nausea and vomiting. Anesth Analg. 2004; 99(4): 1070–1075.
    CrossRefPubMed
  67. Bao T, Cai L, Giles JT, et al. A dual-center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors. Breast Cancer Res Treat. 2013; 138(1): 167–174.
    CrossRefPubMed
  68. Crew KD, Capodice JL, Greenlee H, et al. Pilot study of acupuncture for the treatment of joint symptoms related to adjuvant aromatase inhibitor therapy in postmenopausal breast cancer patients. J Cancer Surviv. 2007; 1(4): 283–291.
    CrossRefPubMed
  69. Crew KD, Capodice JL, Greenlee H, et al. Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol. 2010; 28(7): 1154–1160.
    CrossRefPubMed
  70. Siedentopf F, Utz-Billing I, Gairing S, et al. Yoga for patients with early breast cancer and its impact on quality of life — a randomized controlled trial. Geburtshilfe Frauenheilkd. 2013; 73(4): 311–317.
    CrossRefPubMed
  71. Raghavendra RM, Nagarathna R, Nagendra HR, et al. Effects of an integrated yoga programme on chemotherapy-induced nausea and emesis in breast cancer patients. Eur J Cancer Care (Engl). 2007; 16(6): 462–474.
    CrossRefPubMed
  72. Pruthi S, Stan DL, Jenkins SM, et al. A randomized controlled pilot study assessing feasibility and impact of yoga practice on quality of life, mood, and perceived stress in women with newly diagnosed breast cancer. Glob Adv Health Med. 2012; 1(5): 30–35.
    CrossRefPubMed
  73. Edwards GV, Aherne NJ, Horsley PJ, et al. Prevalence of complementary and alternative therapy use by cancer patients undergoing radiation therapy. Asia Pac J Clin Oncol. 2014; 10(4): 346–353.
    CrossRefPubMed

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