The effect of sarcopenia on survival in patients with metastatic colon cancer
, 2, 3, 4
Abstract
Introduction. Sarcopenia is a common loss of muscle mass in cancer patients. The aim of this study is to investigate the effect of sarcopenia on survival in patients with metastatic colon cancer.
Material and methods. The study was carried out retrospectively in patients diagnosed with metastatic colon cancer between January 2016 and December 2023. Sarcopenic patients were determined by total psoas area index and Hounsfield unit average calculation using computed tomography scan images obtained at the time of diagnosis. Statistical analyses were performed using Windows SPSS 20 package program. The effects of sarcopenia on survival were analyzed using the log-rank test, and univariate Cox regression analysis was applied to evaluate clinicopathological features. A p-value < 0.05 was considered statistically significant.
Results. A total of 70 patients with metastatic colon cancer were evaluated. Sarcopenia was detected in 18 patients (25.7%). The median age of the sarcopenic patients was 72 (53–83) years. A significant correlation was found between age and sarcopenia (p = 0.002). Median survival of sarcopenic patients was 11 months while non-sarcopenic patients had a median survival of 24 months. A difference was found in overall survival between the two groups (p = 0.021). There was no difference in progression free survival between sarcopenic and non-sarcopenic patients (p = 0.615).
Conclusions. In the present study, a significant prognostic effect of sarcopenia on survival was found in patients with metastatic colon cancer. The survival of sarcopenic patients was poorer.
Keywords: colon cancersarcopeniametastasis
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