open access
Biological aspects of anticancer therapy with platinum drugs: interactions with cytochrome c
open access
Abstract
Platinum-based drugs are widely used in the clinical treatment of various cancers, however their toxic side effects, like concentration-dependent nephrotoxicity and resistance limit their usage. Cytochrome c is a small electron-carrier heme protein, located in the mitochondria, that plays a crucial role in apoptotic pathways. Platination of specific side chains, which can affect the function of biologically crucial proteins and enzymes through the formation of strong coordinative bonds, might play a relevant role in the overall mechanism and toxicity of platinum drugs. To understand the nature of those interactions, we have analysed the reactions of anticancer platinum drugs with cytochrome c — signalling apoptotic protein.
Abstract
Platinum-based drugs are widely used in the clinical treatment of various cancers, however their toxic side effects, like concentration-dependent nephrotoxicity and resistance limit their usage. Cytochrome c is a small electron-carrier heme protein, located in the mitochondria, that plays a crucial role in apoptotic pathways. Platination of specific side chains, which can affect the function of biologically crucial proteins and enzymes through the formation of strong coordinative bonds, might play a relevant role in the overall mechanism and toxicity of platinum drugs. To understand the nature of those interactions, we have analysed the reactions of anticancer platinum drugs with cytochrome c — signalling apoptotic protein.
About this articleTitle
Biological aspects of anticancer therapy with platinum drugs: interactions with cytochrome c
Journal
Nowotwory. Journal of Oncology
Issue
Article type
Review paper
Pages
136-150
Published online
2016-06-01
Page views
752
Article views/downloads
4508
DOI
Bibliographic record
Nowotwory. Journal of Oncology 2016;66(2):136-150.
Authors
Urszula Śliwińska-Hill
Marta Szumełda