open access

Vol 66, No 2 (2016)
Review paper
Published online: 2016-06-01
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Biological aspects of anticancer therapy with platinum drugs: interactions with cytochrome c

Urszula Śliwińska-Hill, Marta Szumełda
DOI: 10.5603/NJO.2016.0023
·
Nowotwory. Journal of Oncology 2016;66(2):136-150.

open access

Vol 66, No 2 (2016)
Review article
Published online: 2016-06-01

Abstract

Platinum-based drugs are widely used in the clinical treatment of various cancers, however their toxic side effects, like concentration-dependent nephrotoxicity and resistance limit their usage. Cytochrome c is a small electron-carrier heme protein, located in the mitochondria, that plays a crucial role in apoptotic pathways. Platination of specific side chains, which can affect the function of biologically crucial proteins and enzymes through the formation of strong coordinative bonds, might play a relevant role in the overall mechanism and toxicity of platinum drugs. To understand the nature of those interactions, we have analysed the reactions of anticancer platinum drugs with cytochrome c — signalling apoptotic protein.

Abstract

Platinum-based drugs are widely used in the clinical treatment of various cancers, however their toxic side effects, like concentration-dependent nephrotoxicity and resistance limit their usage. Cytochrome c is a small electron-carrier heme protein, located in the mitochondria, that plays a crucial role in apoptotic pathways. Platination of specific side chains, which can affect the function of biologically crucial proteins and enzymes through the formation of strong coordinative bonds, might play a relevant role in the overall mechanism and toxicity of platinum drugs. To understand the nature of those interactions, we have analysed the reactions of anticancer platinum drugs with cytochrome c — signalling apoptotic protein.

Get Citation
About this article
Title

Biological aspects of anticancer therapy with platinum drugs: interactions with cytochrome c

Journal

Nowotwory. Journal of Oncology

Issue

Vol 66, No 2 (2016)

Article type

Review paper

Pages

136-150

Published online

2016-06-01

DOI

10.5603/NJO.2016.0023

Bibliographic record

Nowotwory. Journal of Oncology 2016;66(2):136-150.

Authors

Urszula Śliwińska-Hill
Marta Szumełda

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