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open access

Vol 57, No 3 (2023)
Research Paper
Submitted: 2023-02-04
Accepted: 2023-04-13
Published online: 2023-05-10
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Predictors of falls in Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy: a retrospective study

Christian F. Altmann1, Jiri Koschel2, Wolfgang H Jost1
DOI: 10.5603/PJNNS.a2023.0036
·
Pubmed: 37161947
·
Neurol Neurochir Pol 2023;57(3):297-304.
Affiliations
  1. Parkinson-Klinik Ortenau, Wolfach, Germany
  2. Department of Neurology, University of Saarland, Homburg/Saar, Germany

open access

Vol 57, No 3 (2023)
Research papers
Submitted: 2023-02-04
Accepted: 2023-04-13
Published online: 2023-05-10

Abstract

Introduction. Recurrent falling is a major clinical milestone in Parkinsonian syndromes. It has a detrimental impact on quality of life, further prognosis, and life expectancy.

Aim of the study. To improve fall management and prevention, we aimed at identifying clinical parameters predicting fall frequency. To this end, we retrospectively analysed records of fall events of patients with Parkinson’s disease (PD), or progressive supranuclear palsy (PSP), or multiple system atrophy (MSA), during their two-week inpatient stay at the Parkinson-Klinik Ortenau, Wolfach, Germany. This data served as an objective proxy for patients’ fall frequency and allowed us to estimate the impact of several demographic and clinical variables on the occurrence of falling.

Material and methods. Of 2,111 patients admitted to our hospital, 1,810 presented with PD, 191 with PSP, and 110 with MSA. We employed a multiple (quasi-) poisson regression analysis to model the fall frequency as a function of various demographic variables (age at diagnosis, gender) and clinical variables (disease duration and sub-type, motor and cognitive impairment, autonomic dysfunction).

Results. Statistically significant predictors for falls in PD were cognitive impairment, motor impairment, and autonomic dysfunction. In PSP, significant predictors for falls were motor and autonomic dysfunction, while in MSA only disease duration predicted falls, but with only marginal statistical significance.

Conclusions. Our results stress the importance of different factors in predicting falls in the different types of Parkinsonian syndrome. Preventive interventions should address these disease-specific targets for optimal success.

Abstract

Introduction. Recurrent falling is a major clinical milestone in Parkinsonian syndromes. It has a detrimental impact on quality of life, further prognosis, and life expectancy.

Aim of the study. To improve fall management and prevention, we aimed at identifying clinical parameters predicting fall frequency. To this end, we retrospectively analysed records of fall events of patients with Parkinson’s disease (PD), or progressive supranuclear palsy (PSP), or multiple system atrophy (MSA), during their two-week inpatient stay at the Parkinson-Klinik Ortenau, Wolfach, Germany. This data served as an objective proxy for patients’ fall frequency and allowed us to estimate the impact of several demographic and clinical variables on the occurrence of falling.

Material and methods. Of 2,111 patients admitted to our hospital, 1,810 presented with PD, 191 with PSP, and 110 with MSA. We employed a multiple (quasi-) poisson regression analysis to model the fall frequency as a function of various demographic variables (age at diagnosis, gender) and clinical variables (disease duration and sub-type, motor and cognitive impairment, autonomic dysfunction).

Results. Statistically significant predictors for falls in PD were cognitive impairment, motor impairment, and autonomic dysfunction. In PSP, significant predictors for falls were motor and autonomic dysfunction, while in MSA only disease duration predicted falls, but with only marginal statistical significance.

Conclusions. Our results stress the importance of different factors in predicting falls in the different types of Parkinsonian syndrome. Preventive interventions should address these disease-specific targets for optimal success.

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Keywords

autonomic dysfunction, cognitive impairment, falls, multiple system atrophy, Parkinson’s disease, progressive supranuclear palsy

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Title

Predictors of falls in Parkinson’s disease, progressive supranuclear palsy, and multiple system atrophy: a retrospective study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 57, No 3 (2023)

Article type

Research Paper

Pages

297-304

Published online

2023-05-10

Page views

1560

Article views/downloads

589

DOI

10.5603/PJNNS.a2023.0036

Pubmed

37161947

Bibliographic record

Neurol Neurochir Pol 2023;57(3):297-304.

Keywords

autonomic dysfunction
cognitive impairment
falls
multiple system atrophy
Parkinson’s disease
progressive supranuclear palsy

Authors

Christian F. Altmann
Jiri Koschel
Wolfgang H Jost

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