open access

Vol 55, No 3 (2021)
Review Article
Submitted: 2020-12-23
Accepted: 2021-01-20
Published online: 2021-02-04
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Genetics of Parkinson’s disease in the Polish population

Łukasz M. Milanowski123, Owen A. Ross2, Andrzej Friedman3, Dorota Hoffman-Zacharska4, Paulina Gorka-Skoczylas4, Marta Jurek4, Dariusz Koziorowski3, Zbigniew K. Wszolek1
·
Pubmed: 33539026
·
Neurol Neurochir Pol 2021;55(3):241-252.
Affiliations
  1. Department of Neurology, Mayo Clinic Florida, United States
  2. Department of Neuroscience, Mayo Clinic Florida, Jacksonville, United States
  3. Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Poland
  4. Department of Medical Genetics, Institute of the Mother and Child, Warsaw, 01-211, Poland

open access

Vol 55, No 3 (2021)
Review articles
Submitted: 2020-12-23
Accepted: 2021-01-20
Published online: 2021-02-04

Abstract

Introduction. Genetic forms of Parkinson’s disease (PD) often cluster in different ethnic groups and may present with recognisable unique clinical manifestations. Our aim was to summarise the current state of knowledge regarding the genetic causes of PD and describe the first Polish patient with SNCA duplication.

Methodology. We searched the electronic database, PubMed, for studies between January 1995 and June 2020 that evaluated genetics in Polish patients with PD, using the search terms ‘Parkinson’s disease, ‘Polish’, ‘genetics’, ‘mutations’, and ‘variants’.

Results. In total, 73 publications were included in the review; 11 genes responsible for monogenic forms and 19 risk factor genes have been analysed in the Polish population. Pathogenic variants were reported in four monogenic genes (LRRK2, PRKN, PINK1, and SNCA). Eight genes were associated with PD risk in the Polish population (GBA, TFAM, NFE2L2, MMP12, HLA-DRA, COMT, MAOB, and DBH). Multiplex ligation-dependent probe amplification and Sanger sequencing in PRKN, PINK1, DJ1, LRRK2, and SNCA revealed SNCA duplication in a 43-year-old Polish patient with PD examined by movement disorder specialists.

Conclusion. Only a limited number of positive results have been reported in genes previously associated with PD in the Polish population. In the era of personalised medicine, it is important to report on genetic findings in specific populations.

Abstract

Introduction. Genetic forms of Parkinson’s disease (PD) often cluster in different ethnic groups and may present with recognisable unique clinical manifestations. Our aim was to summarise the current state of knowledge regarding the genetic causes of PD and describe the first Polish patient with SNCA duplication.

Methodology. We searched the electronic database, PubMed, for studies between January 1995 and June 2020 that evaluated genetics in Polish patients with PD, using the search terms ‘Parkinson’s disease, ‘Polish’, ‘genetics’, ‘mutations’, and ‘variants’.

Results. In total, 73 publications were included in the review; 11 genes responsible for monogenic forms and 19 risk factor genes have been analysed in the Polish population. Pathogenic variants were reported in four monogenic genes (LRRK2, PRKN, PINK1, and SNCA). Eight genes were associated with PD risk in the Polish population (GBA, TFAM, NFE2L2, MMP12, HLA-DRA, COMT, MAOB, and DBH). Multiplex ligation-dependent probe amplification and Sanger sequencing in PRKN, PINK1, DJ1, LRRK2, and SNCA revealed SNCA duplication in a 43-year-old Polish patient with PD examined by movement disorder specialists.

Conclusion. Only a limited number of positive results have been reported in genes previously associated with PD in the Polish population. In the era of personalised medicine, it is important to report on genetic findings in specific populations.

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Keywords

genetics, Parkinson’s disease, Polish population, SNCA duplication

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About this article
Title

Genetics of Parkinson’s disease in the Polish population

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 55, No 3 (2021)

Article type

Review Article

Pages

241-252

Published online

2021-02-04

Page views

1916

Article views/downloads

1107

DOI

10.5603/PJNNS.a2021.0013

Pubmed

33539026

Bibliographic record

Neurol Neurochir Pol 2021;55(3):241-252.

Keywords

genetics
Parkinson’s disease
Polish population
SNCA duplication

Authors

Łukasz M. Milanowski
Owen A. Ross
Andrzej Friedman
Dorota Hoffman-Zacharska
Paulina Gorka-Skoczylas
Marta Jurek
Dariusz Koziorowski
Zbigniew K. Wszolek

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